diff --git a/core/src/components/alert/alert.tsx b/core/src/components/alert/alert.tsx
index 89a13a3d3b6..af023a167de 100644
--- a/core/src/components/alert/alert.tsx
+++ b/core/src/components/alert/alert.tsx
@@ -584,12 +584,14 @@ export class Alert implements ComponentInterface, OverlayInterface {
     const subHdrId = `alert-${overlayIndex}-sub-hdr`;
     const msgId = `alert-${overlayIndex}-msg`;
     const role = this.inputs.length > 0 || this.buttons.length > 0 ? 'alertdialog' : 'alert';
+    const defaultAriaLabel = header || subHeader || 'Alert';
 
     return (
       <Host
         role={role}
         aria-modal="true"
         tabindex="-1"
+        aria-label={defaultAriaLabel}
         {...(htmlAttributes as any)}
         style={{
           zIndex: `${20000 + overlayIndex}`,
diff --git a/core/src/components/alert/test/a11y/alert.e2e.ts b/core/src/components/alert/test/a11y/alert.e2e.ts
new file mode 100644
index 00000000000..74746af7cc7
--- /dev/null
+++ b/core/src/components/alert/test/a11y/alert.e2e.ts
@@ -0,0 +1,43 @@
+import AxeBuilder from '@axe-core/playwright';
+import { expect } from '@playwright/test';
+import type { E2EPage } from '@utils/test/playwright';
+import { test } from '@utils/test/playwright';
+
+const testAriaLabel = async (page: E2EPage, buttonID: string, expectedAriaLabel: string) => {
+  const button = page.locator(`#${buttonID}`);
+  await button.click();
+
+  const alert = page.locator('ion-alert');
+  await expect(alert).toHaveAttribute('aria-label', expectedAriaLabel);
+};
+
+test.describe('alert: a11y', () => {
+  test.beforeEach(async ({ page, skip }) => {
+    skip.rtl();
+    await page.goto(`/src/components/alert/test/a11y`);
+  });
+
+  test('should not have accessibility violations', async ({ page }) => {
+    const button = page.locator('#customHeader');
+    await button.click();
+
+    const results = await new AxeBuilder({ page }).analyze();
+    expect(results.violations).toEqual([]);
+  });
+
+  test('should have fallback aria-label when no header or subheader is specified', async ({ page }) => {
+    await testAriaLabel(page, 'noHeader', 'Alert');
+  });
+
+  test('should inherit aria-label from header', async ({ page }) => {
+    await testAriaLabel(page, 'customHeader', 'Header');
+  });
+
+  test('should inherit aria-label from subheader if no header is specified', async ({ page }) => {
+    await testAriaLabel(page, 'subHeaderOnly', 'Subtitle');
+  });
+
+  test('should allow for manually specifying aria-label', async ({ page }) => {
+    await testAriaLabel(page, 'customAriaLabel', 'Custom alert');
+  });
+});
diff --git a/core/src/components/alert/test/a11y/index.html b/core/src/components/alert/test/a11y/index.html
new file mode 100644
index 00000000000..a457eef9e2f
--- /dev/null
+++ b/core/src/components/alert/test/a11y/index.html
@@ -0,0 +1,75 @@
+<!DOCTYPE html>
+<html lang="en" dir="ltr">
+  <head>
+    <meta charset="UTF-8" />
+    <title>Alert - A11y</title>
+    <meta name="viewport" content="width=device-width, initial-scale=1.0, minimum-scale=1.0" />
+    <link href="../../../../../css/ionic.bundle.css" rel="stylesheet" />
+    <link href="../../../../../scripts/testing/styles.css" rel="stylesheet" />
+    <script src="../../../../../scripts/testing/scripts.js"></script>
+    <script nomodule src="../../../../../dist/ionic/ionic.js"></script>
+    <script type="module" src="../../../../../dist/ionic/ionic.esm.js"></script>
+  </head>
+  <script type="module">
+    import { alertController } from '../../../../dist/ionic/index.esm.js';
+    window.alertController = alertController;
+  </script>
+
+  <body>
+    <main class="ion-padding">
+      <h1>Alert - A11y</h1>
+
+      <ion-button id="noHeader" expand="block" onclick="presentNoHeader()">Alert With No Header</ion-button>
+      <ion-button id="customHeader" expand="block" onclick="presentCustomHeader()">Alert With Custom Header</ion-button>
+      <ion-button id="subHeaderOnly" expand="block" onclick="presentSubHeaderOnly()"
+        >Alert With Subheader Only</ion-button
+      >
+      <ion-button id="customAriaLabel" expand="block" onclick="presentCustomAriaLabel()"
+        >Alert With Custom Aria Label</ion-button
+      >
+    </main>
+
+    <script>
+      async function openAlert(opts) {
+        const alert = await alertController.create(opts);
+        await alert.present();
+      }
+
+      function presentNoHeader() {
+        openAlert({
+          message: 'This is an alert message.',
+          buttons: ['OK'],
+        });
+      }
+
+      function presentCustomHeader() {
+        openAlert({
+          header: 'Header',
+          subHeader: 'Subtitle',
+          message: 'This is an alert message.',
+          buttons: ['OK'],
+        });
+      }
+
+      function presentSubHeaderOnly() {
+        openAlert({
+          subHeader: 'Subtitle',
+          message: 'This is an alert message.',
+          buttons: ['OK'],
+        });
+      }
+
+      function presentCustomAriaLabel() {
+        openAlert({
+          header: 'Header',
+          subHeader: 'Subtitle',
+          message: 'This is an alert message with a custom aria-label.',
+          buttons: ['OK'],
+          htmlAttributes: {
+            'aria-label': 'Custom alert',
+          },
+        });
+      }
+    </script>
+  </body>
+</html>
