diff --git a/ipykernel/debugger.py b/ipykernel/debugger.py
index 44c9d16e9..62c6a5407 100644
--- a/ipykernel/debugger.py
+++ b/ipykernel/debugger.py
@@ -8,6 +8,7 @@
 from tornado.locks import Event
 
 from IPython.core.getipython import get_ipython
+from IPython.core.inputtransformer2 import leading_empty_lines
 
 try:
     from jupyter_client.jsonutil import json_default
@@ -286,6 +287,7 @@ def __init__(self, log, debugpy_stream, event_callback, shell_socket, session):
         self.stopped_threads = []
 
         self.debugpy_initialized = False
+        self._removed_cleanup = {}
 
         self.debugpy_host = '127.0.0.1'
         self.debugpy_port = 0
@@ -341,12 +343,25 @@ def start(self):
 
             ident, msg = self.session.recv(self.shell_socket, mode=0)
             self.debugpy_initialized = msg['content']['status'] == 'ok'
+
+        # Don't remove leading empty lines when debugging so the breakpoints are correctly positioned
+        cleanup_transforms = get_ipython().input_transformer_manager.cleanup_transforms
+        if leading_empty_lines in cleanup_transforms:
+            index = cleanup_transforms.index(leading_empty_lines)
+            self._removed_cleanup[index] = cleanup_transforms.pop(index)
+
         self.debugpy_client.connect_tcp_socket()
         return self.debugpy_initialized
 
     def stop(self):
         self.debugpy_client.disconnect_tcp_socket()
 
+        # Restore remove cleanup transformers
+        cleanup_transforms = get_ipython().input_transformer_manager.cleanup_transforms
+        for index in sorted(self._removed_cleanup):
+            func = self._removed_cleanup.pop(index)
+            cleanup_transforms.insert(index, func)
+
     async def dumpCell(self, message):
         code = message['arguments']['code']
         file_name = get_file_name(code)
diff --git a/ipykernel/tests/test_debugger.py b/ipykernel/tests/test_debugger.py
index d7263ca9b..ab9f13a2c 100644
--- a/ipykernel/tests/test_debugger.py
+++ b/ipykernel/tests/test_debugger.py
@@ -1,6 +1,7 @@
+import sys
 import pytest
 
-from .utils import new_kernel, get_reply
+from .utils import TIMEOUT, new_kernel, get_reply
 
 seq = 0
 
@@ -8,7 +9,7 @@
 pytest.importorskip("debugpy")
 
 
-def wait_for_debug_request(kernel, command, arguments=None):
+def wait_for_debug_request(kernel, command, arguments=None, full_reply=False):
     """Carry out a debug request and return the reply content.
 
     It does not check if the request was successful.
@@ -27,7 +28,7 @@ def wait_for_debug_request(kernel, command, arguments=None):
     )
     kernel.control_channel.send(msg)
     reply = get_reply(kernel, msg["header"]["msg_id"], channel="control")
-    return reply["content"]
+    return reply if full_reply else reply["content"]
 
 
 @pytest.fixture
@@ -127,6 +128,76 @@ def test_set_breakpoints(kernel_with_debug):
     assert r["success"]
 
 
+def test_stop_on_breakpoint(kernel_with_debug):
+    code = """def f(a, b):
+    c = a + b
+    return c
+
+f(2, 3)"""
+
+    r = wait_for_debug_request(kernel_with_debug, "dumpCell", {"code": code})
+    source = r["body"]["sourcePath"]
+
+    wait_for_debug_request(kernel_with_debug, "debugInfo")
+
+    wait_for_debug_request(
+        kernel_with_debug,
+        "setBreakpoints",
+        {
+            "breakpoints": [{"line": 2}],
+            "source": {"path": source},
+            "sourceModified": False,
+        },
+    )
+
+    wait_for_debug_request(kernel_with_debug, "configurationDone", full_reply=True)
+
+    kernel_with_debug.execute(code)
+    
+    # Wait for stop on breakpoint
+    msg = {"msg_type": "", "content": {}}
+    while msg.get('msg_type') != 'debug_event' or msg["content"].get("event") != "stopped":
+        msg = kernel_with_debug.get_iopub_msg(timeout=TIMEOUT)
+
+    assert msg["content"]["body"]["reason"] == "breakpoint"
+
+
+@pytest.mark.skipif(sys.version_info >= (3, 10), reason="TODO Does not work on Python 3.10")
+def test_breakpoint_in_cell_with_leading_empty_lines(kernel_with_debug):
+    code = """
+def f(a, b):
+    c = a + b
+    return c
+
+f(2, 3)"""
+
+    r = wait_for_debug_request(kernel_with_debug, "dumpCell", {"code": code})
+    source = r["body"]["sourcePath"]
+
+    wait_for_debug_request(kernel_with_debug, "debugInfo")
+
+    wait_for_debug_request(
+        kernel_with_debug,
+        "setBreakpoints",
+        {
+            "breakpoints": [{"line": 6}],
+            "source": {"path": source},
+            "sourceModified": False,
+        },
+    )
+
+    wait_for_debug_request(kernel_with_debug, "configurationDone", full_reply=True)
+
+    kernel_with_debug.execute(code)
+    
+    # Wait for stop on breakpoint
+    msg = {"msg_type": "", "content": {}}
+    while msg.get('msg_type') != 'debug_event' or msg["content"].get("event") != "stopped":
+        msg = kernel_with_debug.get_iopub_msg(timeout=TIMEOUT)
+
+    assert msg["content"]["body"]["reason"] == "breakpoint"
+
+
 def test_rich_inspect_not_at_breakpoint(kernel_with_debug):
     var_name = "text"
     value = "Hello the world"