diff --git a/CRD-DTR/DrugHasREMS/R4/files/DrugHasREMSRule-0.1.0.cql b/CRD-DTR/DrugHasREMS/R4/files/DrugHasREMSRule-0.1.0.cql
index 1880876..f84aeba 100644
--- a/CRD-DTR/DrugHasREMS/R4/files/DrugHasREMSRule-0.1.0.cql
+++ b/CRD-DTR/DrugHasREMS/R4/files/DrugHasREMSRule-0.1.0.cql
@@ -19,6 +19,16 @@ define DOCUMENTATION_REQUIRED:
 
 define RESULT_InfoLink:
     'https://www.accessdata.fda.gov/drugsatfda_docs/rems/Turalio_2020_08_04_REMS_Full.pdf'
+define INFO_PATIENT_MedicationGuide:
+    'https://daiichisankyo.us/prescribing-information-portlet/getPIContent?productName=Turalio_Med&inline=true'
+define INFO_PATIENT_PatientGuide:
+    'https://www.accessdata.fda.gov/drugsatfda_docs/rems/Turalio_2020_12_16_Patient_Guide.pdf'
+define INFO_PRESCRIBER_PrescribingInformation:
+    'https://daiichisankyo.us/prescribing-information-portlet/getPIContent?productName=Turalio&inline=true'
+define INFO_PRESCRIBER_ProgramOverview:
+    'https://www.accessdata.fda.gov/drugsatfda_docs/rems/Turalio_2020_12_16_Program_Overview.pdf'
+define INFO_PRESCRIBER_PrescriberTraining:
+    'https://www.accessdata.fda.gov/drugsatfda_docs/rems/Turalio_2020_12_16_Prescriber_Training.pdf'
 
 define RESULT_QuestionnaireOrderUri:
     'Questionnaire/TuralioRemsPatientEnrollment'  
diff --git a/CRD-DTR/IPledge/R4/files/IPledgeRule-0.1.0.cql b/CRD-DTR/IPledge/R4/files/IPledgeRule-0.1.0.cql
index fa8856a..9ecc441 100644
--- a/CRD-DTR/IPledge/R4/files/IPledgeRule-0.1.0.cql
+++ b/CRD-DTR/IPledge/R4/files/IPledgeRule-0.1.0.cql
@@ -18,7 +18,19 @@ define DOCUMENTATION_REQUIRED:
   true
   
 define RESULT_InfoLink:
-    'https://www.accessdata.fda.gov/drugsatfda_docs/rems/IPledge_2020_08_04_REMS_Full.pdf'
+    'https://www.accessdata.fda.gov/drugsatfda_docs/rems/Isotretinoin_2021_10_8_REMS_Document.pdf'
+
+define INFO_PATIENT_FactSheet:
+    'https://www.accessdata.fda.gov/drugsatfda_docs/rems/Isotretinoin_2021_10_8_Fact_Sheet.pdf'
+
+define INFO_PATIENT_GuideForPatientsWhoCanGetPregnant:
+    'https://www.accessdata.fda.gov/drugsatfda_docs/rems/Isotretinoin_2021_10_8_Guide_for_Patients_Who_Can_Get_pregnant.pdf'
+define INFO_PATIENT_ContraceptiveCounselingGuide:
+    'https://www.accessdata.fda.gov/drugsatfda_docs/rems/Isotretinoin_2021_10_8_Contraception_Counseling_Guide.pdf'
+define INFO_PRESCRIBER_PrescriberGuide:
+    'https://www.accessdata.fda.gov/drugsatfda_docs/rems/Isotretinoin_2021_10_8_Prescriber_Guide.pdf'
+define INFO_PRESCRIBER_ComprehensionQuestions:
+    'https://www.accessdata.fda.gov/drugsatfda_docs/rems/Isotretinoin_2021_10_8_Comprehension_Questions.pdf'
 
 define RESULT_QuestionnaireOrderUri:
     'Questionnaire/IPledgeRemsPatientEnrollment'
diff --git a/CRD-DTR/TIRF/R4/files/TIRFRule-0.1.0.cql b/CRD-DTR/TIRF/R4/files/TIRFRule-0.1.0.cql
index c837c3d..ec5dd2a 100644
--- a/CRD-DTR/TIRF/R4/files/TIRFRule-0.1.0.cql
+++ b/CRD-DTR/TIRF/R4/files/TIRFRule-0.1.0.cql
@@ -18,7 +18,15 @@ define DOCUMENTATION_REQUIRED:
   true
 
 define RESULT_InfoLink:
-    'https://www.accessdata.fda.gov/drugsatfda_docs/rems/TIRF_2020_08_04_REMS_Full.pdf'
+    'https://www.accessdata.fda.gov/drugsatfda_docs/rems/TIRF_2022_08_17_REMS_Document.pdf'
+define INFO_PATIENT_PatientCounselingGuide:
+    'https://www.accessdata.fda.gov/drugsatfda_docs/rems/TIRF_2022_08_17_Patient_Counseling_Guide.pdf'
+define INFO_PATIENT_PatientFAQ:
+    'https://tirfstorageproduction.blob.core.windows.net/tirf-public/tirf-patientfaq-frequently-asked-questions.pdf?skoid=417a7522-f809-43c4-b6a8-6b192d44b69e&sktid=59fc620e-de8c-4745-abcc-18182d1bf20e&skt=2022-09-20T19%3A06%3A21Z&ske=2022-09-26T19%3A11%3A21Z&sks=b&skv=2020-04-08&sv=2020-04-08&st=2021-03-21T21%3A27%3A00Z&se=2031-03-21T23%3A59%3A59Z&sr=b&sp=rc&sig=owSGAoUBZuCtsLE41F2XC3o12x%2BG%2Bt5ogykOIt796es%3D'
+define INFO_PRESCRIBER_PrescriberEducation:
+    'https://www.accessdata.fda.gov/drugsatfda_docs/rems/TIRF_2022_08_17_Prescriber_Education.pdf'
+define INFO_PRESCRIBER_PrescriberFAQ:
+    'https://tirfstorageproduction.blob.core.windows.net/tirf-public/tirf-prfaq-frequently-asked-questions.pdf?skoid=417a7522-f809-43c4-b6a8-6b192d44b69e&sktid=59fc620e-de8c-4745-abcc-18182d1bf20e&skt=2022-09-20T19%3A06%3A53Z&ske=2022-09-26T19%3A11%3A53Z&sks=b&skv=2020-04-08&sv=2020-04-08&st=2021-03-21T21%3A35%3A43Z&se=2031-03-21T23%3A59%3A59Z&sr=b&sp=rc&sig=fqtDzsm7qi1G8MKau210Y3gNet%2Fi20zw2EThKODdEUM%3D'
 
 define RESULT_QuestionnaireOrderUri:
     'Questionnaire/TIRFRemsPatientEnrollment'