diff --git a/src/agent/agentLoader.ts b/src/agent/agentLoader.ts
index 0998523c..ecddff37 100644
--- a/src/agent/agentLoader.ts
+++ b/src/agent/agentLoader.ts
@@ -120,6 +120,8 @@ export class AgentLoader {
             console.log(msg);
             return;
         }
+        // Detect and report OpenTelemetry globals before attempting to load the agent
+        this._detectOpenTelemetryGlobals();
         if (this._validate()) {
             try {
                 // Set environment variable to auto attach so the distro is aware of the attach state
@@ -195,6 +197,73 @@ export class AgentLoader {
         }
     }
 
+    private _detectOpenTelemetryGlobals(): void {
+        try {
+            const detectedProviders: string[] = [];
+
+            // Check for OpenTelemetry globals directly on the global object
+            // The OpenTelemetry API stores globals using Symbol.for('opentelemetry.js.api.<major>')
+            // This avoids calling the API methods which could have side effects
+            // Try v1 first, then fallback to v2 for future compatibility
+            const otelSymbolV1 = Symbol.for('opentelemetry.js.api.1');
+            const otelSymbolV2 = Symbol.for('opentelemetry.js.api.2');
+            const otelGlobal = (global as any)[otelSymbolV1] || (global as any)[otelSymbolV2];
+
+            if (otelGlobal) {
+                // Check for registered TracerProvider
+                if (otelGlobal["trace"]) {
+                    const traceProviderName = otelGlobal["trace"]?.constructor?.name;
+                    // ProxyTracerProvider wraps the real provider - check the delegate
+                    if (traceProviderName === 'ProxyTracerProvider') {
+                        const delegateName = otelGlobal["trace"]?._delegate?.constructor?.name;
+                        if (delegateName && delegateName !== 'NoopTracerProvider') {
+                            detectedProviders.push('TracerProvider');
+                        }
+                    } else if (traceProviderName && traceProviderName !== 'NoopTracerProvider') {
+                        detectedProviders.push('TracerProvider');
+                    }
+                }
+
+                // Check for registered MeterProvider
+                if (otelGlobal["metrics"] && otelGlobal["metrics"]?.constructor?.name !== 'ProxyMeterProvider' && otelGlobal["metrics"].constructor.name !== 'NoopMeterProvider') {
+                    detectedProviders.push('MeterProvider');
+                }
+            }
+
+            // Check for registered LoggerProvider - uses a different symbol and stores a getter function
+            const logsSymbol = Symbol.for('io.opentelemetry.js.api.logs');
+            const logsGlobal = (global as any)[logsSymbol];
+            if (typeof logsGlobal === 'function') {
+                // logsGlobal is a getter function that takes a version number and returns the provider
+                // Try both API compatibility versions (1 and 2) to support different @opentelemetry/api-logs versions
+                let logsProvider = logsGlobal(1); // Try v1 first
+                if (!logsProvider || logsProvider.constructor?.name === 'NoopLoggerProvider') {
+                    logsProvider = logsGlobal(2); // Try v2 if v1 returns NOOP
+                }
+                const loggerProviderName = logsProvider?.constructor?.name;
+                if (
+                    loggerProviderName &&
+                    loggerProviderName !== 'ProxyLoggerProvider' &&
+                    loggerProviderName !== 'NoopLoggerProvider'
+                ) {
+                    detectedProviders.push('LoggerProvider');
+                }
+            }
+
+            if (detectedProviders.length > 0 && this._diagnosticLogger) {
+                const msg = `OpenTelemetry global providers detected while using Application Insights auto-attach: ${detectedProviders.join(', ')}. `;
+                const diagnosticLog = {
+                    message: msg,
+                    messageId: DiagnosticMessageId.openTelemetryConflict
+                } as IDiagnosticLog;
+                this._diagnosticLogger.logMessage(diagnosticLog);
+            }
+        }
+        catch (err: any) {
+            console.log("Error detecting OpenTelemetry globals: " + err);
+        }
+    }
+
     private _getAuthenticationCredential(): any {
         let credential = undefined;
         // Try to add AAD Token Credential
diff --git a/src/agent/types.ts b/src/agent/types.ts
index add557f6..0b6fbe4c 100644
--- a/src/agent/types.ts
+++ b/src/agent/types.ts
@@ -46,4 +46,5 @@ export const DiagnosticMessageId = {
     "prefixFailed": "3004",
     "aadEnabled": "3005",
     "unknownError": "3006",
+    "openTelemetryConflict": "3007",
 }
diff --git a/test/unitTests/agent/agentLoader.tests.ts b/test/unitTests/agent/agentLoader.tests.ts
index 925c19a7..c7b9c0a9 100644
--- a/test/unitTests/agent/agentLoader.tests.ts
+++ b/test/unitTests/agent/agentLoader.tests.ts
@@ -7,10 +7,18 @@ import sinon from "sinon";
 import { AgentLoader } from "../../../src/agent/agentLoader";
 import * as azureMonitor from "@azure/monitor-opentelemetry";
 import { DiagnosticMessageId } from "../../../src/agent/types";
+import { trace, metrics } from "@opentelemetry/api";
+import { BasicTracerProvider } from "@opentelemetry/sdk-trace-node";
+import { MeterProvider } from "@opentelemetry/sdk-metrics";
+import { logs as otelLogs } from "@opentelemetry/api-logs";
+import { LoggerProvider } from "@opentelemetry/sdk-logs";
 
 describe("agent/agentLoader", () => {
     let originalEnv: NodeJS.ProcessEnv;
     let sandbox: sinon.SinonSandbox;
+    let originalOtelGlobalV1: any;
+    let originalOtelGlobalV2: any;
+    let originalLogsGlobal: any;
 
     const defaultConfig = {
         azureMonitorExporterOptions: {
@@ -51,11 +59,32 @@ describe("agent/agentLoader", () => {
 
     beforeEach(() => {
         originalEnv = process.env;
+        const otelSymbolV1 = Symbol.for('opentelemetry.js.api.1');
+        const otelSymbolV2 = Symbol.for('opentelemetry.js.api.2');
+        const logsSymbol = Symbol.for('io.opentelemetry.js.api.logs');
+        originalOtelGlobalV1 = (global as any)[otelSymbolV1];
+        originalOtelGlobalV2 = (global as any)[otelSymbolV2];
+        originalLogsGlobal = (global as any)[logsSymbol];
     });
 
     afterEach(() => {
         process.env = originalEnv;
         sandbox.restore();
+        const otelSymbolV1 = Symbol.for('opentelemetry.js.api.1');
+        const otelSymbolV2 = Symbol.for('opentelemetry.js.api.2');
+        const logsSymbol = Symbol.for('io.opentelemetry.js.api.logs');
+        (global as any)[otelSymbolV1] = originalOtelGlobalV1;
+        (global as any)[otelSymbolV2] = originalOtelGlobalV2;
+        (global as any)[logsSymbol] = originalLogsGlobal;
+        if (typeof trace.disable === "function") {
+            trace.disable();
+        }
+        if (typeof metrics.disable === "function") {
+            metrics.disable();
+        }
+        if (typeof otelLogs.disable === "function") {
+            otelLogs.disable();
+        }
     });
     
     it("should initialize constructor", () => {
@@ -179,4 +208,45 @@ describe("agent/agentLoader", () => {
         agent["_validate"]();
         assert.deepEqual(statusLoggerStub.args[0][0].AgentInitializedSuccessfully, false);
     });
+
+    it("should log detected OpenTelemetry tracer and meter providers", () => {
+        const env = {
+            ["APPLICATIONINSIGHTS_CONNECTION_STRING"]: "InstrumentationKey=1aa11111-bbbb-1ccc-8ddd-eeeeffff3333",
+        };
+        process.env = env;
+        const tracerProvider = new BasicTracerProvider();
+        trace.setGlobalTracerProvider(tracerProvider);
+        const meterProvider = new MeterProvider();
+        metrics.setGlobalMeterProvider(meterProvider as any);
+
+        const agent = new AgentLoader();
+        const diagnosticLoggerStub = sandbox.stub(agent["_diagnosticLogger"], "logMessage");
+
+        (agent as any)._detectOpenTelemetryGlobals();
+
+        assert.ok(diagnosticLoggerStub.calledOnce);
+        const logged = diagnosticLoggerStub.args[0][0];
+        assert.strictEqual(logged.messageId, DiagnosticMessageId.openTelemetryConflict);
+        assert.ok((logged.message as string).includes("TracerProvider"));
+        assert.ok((logged.message as string).includes("MeterProvider"));
+    });
+
+    it("should log detected OpenTelemetry logger provider via logs symbol getter", () => {
+        const env = {
+            ["APPLICATIONINSIGHTS_CONNECTION_STRING"]: "InstrumentationKey=1aa11111-bbbb-1ccc-8ddd-eeeeffff3333",
+        };
+        process.env = env;
+        const loggerProvider = new LoggerProvider();
+        (otelLogs as any).setGlobalLoggerProvider(loggerProvider);
+
+        const agent = new AgentLoader();
+        const diagnosticLoggerStub = sandbox.stub(agent["_diagnosticLogger"], "logMessage");
+
+        (agent as any)._detectOpenTelemetryGlobals();
+
+        assert.ok(diagnosticLoggerStub.calledOnce);
+        const logged = diagnosticLoggerStub.args[0][0];
+        assert.strictEqual(logged.messageId, DiagnosticMessageId.openTelemetryConflict);
+        assert.ok((logged.message as string).includes("LoggerProvider"));
+    });
 });