diff --git a/change/react-native-windows-25edb5ed-0c39-46dd-a7a7-eaf51aa05c76.json b/change/react-native-windows-25edb5ed-0c39-46dd-a7a7-eaf51aa05c76.json
new file mode 100644
index 00000000000..bdc304a634d
--- /dev/null
+++ b/change/react-native-windows-25edb5ed-0c39-46dd-a7a7-eaf51aa05c76.json
@@ -0,0 +1,7 @@
+{
+  "type": "patch",
+  "comment": "Enable Blob module with runtime option",
+  "packageName": "react-native-windows",
+  "email": "julio.rocha@microsoft.com",
+  "dependentChangeType": "patch"
+}
diff --git a/vnext/Desktop.IntegrationTests/RNTesterIntegrationTests.cpp b/vnext/Desktop.IntegrationTests/RNTesterIntegrationTests.cpp
index ea1183a6a96..0813355bf0a 100644
--- a/vnext/Desktop.IntegrationTests/RNTesterIntegrationTests.cpp
+++ b/vnext/Desktop.IntegrationTests/RNTesterIntegrationTests.cpp
@@ -28,6 +28,7 @@ TEST_MODULE_INITIALIZE(InitModule) {
   SetRuntimeOptionBool("WebSocket.AcceptSelfSigned", true);
   SetRuntimeOptionBool("UseBeastWebSocket", false);
   SetRuntimeOptionBool("Http.UseMonolithicModule", false);
+  SetRuntimeOptionBool("Blob.EnableModule", true);
 
   // WebSocketJSExecutor can't register native log hooks.
   SetRuntimeOptionBool("RNTester.UseWebDebugger", false);
diff --git a/vnext/Shared/Networking/WinRTHttpResource.cpp b/vnext/Shared/Networking/WinRTHttpResource.cpp
index 388d75e8c89..a496186d769 100644
--- a/vnext/Shared/Networking/WinRTHttpResource.cpp
+++ b/vnext/Shared/Networking/WinRTHttpResource.cpp
@@ -68,7 +68,7 @@ void WinRTHttpResource::SendRequest(
     bool withCredentials,
     std::function<void(int64_t)> &&callback) noexcept /*override*/ {
   // Enforce supported args
-  assert(responseType == "text" || responseType == "base64" | responseType == "blob");
+  assert(responseType == "text" || responseType == "base64" || responseType == "blob");
 
   if (callback) {
     callback(requestId);
diff --git a/vnext/Shared/OInstance.cpp b/vnext/Shared/OInstance.cpp
index 10fc8ab630a..ccd58dd3950 100644
--- a/vnext/Shared/OInstance.cpp
+++ b/vnext/Shared/OInstance.cpp
@@ -619,17 +619,20 @@ std::vector<std::unique_ptr<NativeModule>> InstanceImpl::GetDefaultNativeModules
       []() { return std::make_unique<StatusBarManagerModule>(); },
       nativeQueue));
 
-  modules.push_back(std::make_unique<CxxNativeModule>(
-      m_innerInstance,
-      Microsoft::React::GetBlobModuleName(),
-      [transitionalProps]() { return Microsoft::React::CreateBlobModule(transitionalProps); },
-      nativeQueue));
+  // #10036 - Blob module not supported in UWP. Need to define property bag lifetime and onwership.
+  if (Microsoft::React::GetRuntimeOptionBool("Blob.EnableModule")) {
+    modules.push_back(std::make_unique<CxxNativeModule>(
+        m_innerInstance,
+        Microsoft::React::GetBlobModuleName(),
+        [transitionalProps]() { return Microsoft::React::CreateBlobModule(transitionalProps); },
+        nativeQueue));
 
-  modules.push_back(std::make_unique<CxxNativeModule>(
-      m_innerInstance,
-      Microsoft::React::GetFileReaderModuleName(),
-      [transitionalProps]() { return Microsoft::React::CreateFileReaderModule(transitionalProps); },
-      nativeQueue));
+    modules.push_back(std::make_unique<CxxNativeModule>(
+        m_innerInstance,
+        Microsoft::React::GetFileReaderModuleName(),
+        [transitionalProps]() { return Microsoft::React::CreateFileReaderModule(transitionalProps); },
+        nativeQueue));
+  }
 
   return modules;
 }