diff --git a/change/react-native-windows-a8df45ea-26f4-44f5-9b82-712c9aad497e.json b/change/react-native-windows-a8df45ea-26f4-44f5-9b82-712c9aad497e.json
new file mode 100644
index 00000000000..bdc304a634d
--- /dev/null
+++ b/change/react-native-windows-a8df45ea-26f4-44f5-9b82-712c9aad497e.json
@@ -0,0 +1,7 @@
+{
+  "type": "patch",
+  "comment": "Enable Blob module with runtime option",
+  "packageName": "react-native-windows",
+  "email": "julio.rocha@microsoft.com",
+  "dependentChangeType": "patch"
+}
diff --git a/vnext/Desktop.IntegrationTests/RNTesterIntegrationTests.cpp b/vnext/Desktop.IntegrationTests/RNTesterIntegrationTests.cpp
index ea1183a6a96..0813355bf0a 100644
--- a/vnext/Desktop.IntegrationTests/RNTesterIntegrationTests.cpp
+++ b/vnext/Desktop.IntegrationTests/RNTesterIntegrationTests.cpp
@@ -28,6 +28,7 @@ TEST_MODULE_INITIALIZE(InitModule) {
   SetRuntimeOptionBool("WebSocket.AcceptSelfSigned", true);
   SetRuntimeOptionBool("UseBeastWebSocket", false);
   SetRuntimeOptionBool("Http.UseMonolithicModule", false);
+  SetRuntimeOptionBool("Blob.EnableModule", true);
 
   // WebSocketJSExecutor can't register native log hooks.
   SetRuntimeOptionBool("RNTester.UseWebDebugger", false);
diff --git a/vnext/Shared/OInstance.cpp b/vnext/Shared/OInstance.cpp
index 97694c8d330..6bae7ab25ba 100644
--- a/vnext/Shared/OInstance.cpp
+++ b/vnext/Shared/OInstance.cpp
@@ -614,20 +614,20 @@ std::vector<std::unique_ptr<NativeModule>> InstanceImpl::GetDefaultNativeModules
       []() { return std::make_unique<StatusBarManagerModule>(); },
       nativeQueue));
 
-// TODO: Follow up - Blob module not supported in UWP. Need to define property bag lifetime and onwership.
-#if (defined(_MSC_VER) && !defined(WINRT))
-  modules.push_back(std::make_unique<CxxNativeModule>(
-      m_innerInstance,
-      Microsoft::React::GetBlobModuleName(),
-      [transitionalProps]() { return Microsoft::React::CreateBlobModule(transitionalProps); },
-      nativeQueue));
+  // #10036 - Blob module not supported in UWP. Need to define property bag lifetime and onwership.
+  if (Microsoft::React::GetRuntimeOptionBool("Blob.EnableModule")) {
+    modules.push_back(std::make_unique<CxxNativeModule>(
+        m_innerInstance,
+        Microsoft::React::GetBlobModuleName(),
+        [transitionalProps]() { return Microsoft::React::CreateBlobModule(transitionalProps); },
+        nativeQueue));
 
-  modules.push_back(std::make_unique<CxxNativeModule>(
-      m_innerInstance,
-      Microsoft::React::GetFileReaderModuleName(),
-      [transitionalProps]() { return Microsoft::React::CreateFileReaderModule(transitionalProps); },
-      nativeQueue));
-#endif
+    modules.push_back(std::make_unique<CxxNativeModule>(
+        m_innerInstance,
+        Microsoft::React::GetFileReaderModuleName(),
+        [transitionalProps]() { return Microsoft::React::CreateFileReaderModule(transitionalProps); },
+        nativeQueue));
+  }
 
   return modules;
 }