diff --git a/change/react-native-windows-3ee0cf72-a448-421f-a738-e2aac37a7883.json b/change/react-native-windows-3ee0cf72-a448-421f-a738-e2aac37a7883.json
new file mode 100644
index 00000000000..c1e69744372
--- /dev/null
+++ b/change/react-native-windows-3ee0cf72-a448-421f-a738-e2aac37a7883.json
@@ -0,0 +1,7 @@
+{
+  "type": "prerelease",
+  "comment": "Always instantiate Blob module inUWP",
+  "packageName": "react-native-windows",
+  "email": "julio.rocha@microsoft.com",
+  "dependentChangeType": "patch"
+}
diff --git a/vnext/Desktop.DLL/react-native-win32.x64.def b/vnext/Desktop.DLL/react-native-win32.x64.def
index f8d5742909f..eec2862ff77 100644
--- a/vnext/Desktop.DLL/react-native-win32.x64.def
+++ b/vnext/Desktop.DLL/react-native-win32.x64.def
@@ -56,7 +56,6 @@ EXPORTS
 ?makeChakraRuntime@JSI@Microsoft@@YA?AV?$unique_ptr@VRuntime@jsi@facebook@@U?$default_delete@VRuntime@jsi@facebook@@@std@@@std@@$$QEAUChakraRuntimeArgs@12@@Z
 ?Make@IHttpResource@Networking@React@Microsoft@@SA?AV?$shared_ptr@UIHttpResource@Networking@React@Microsoft@@@std@@XZ
 ?CreateTimingModule@react@facebook@@YA?AV?$unique_ptr@VCxxModule@module@xplat@facebook@@U?$default_delete@VCxxModule@module@xplat@facebook@@@std@@@std@@AEBV?$shared_ptr@VMessageQueueThread@react@facebook@@@4@@Z
-??0NetworkingModule@React@Microsoft@@QEAA@XZ
 ?MakeJSQueueThread@ReactNative@Microsoft@@YA?AV?$shared_ptr@VMessageQueueThread@react@facebook@@@std@@XZ
 ?Hash128@SpookyHashV2@hash@folly@@SAXPEBX_KPEA_K2@Z
 ??1Instance@react@facebook@@QEAA@XZ
diff --git a/vnext/Desktop.DLL/react-native-win32.x86.def b/vnext/Desktop.DLL/react-native-win32.x86.def
index d899f933715..f9b316cb1b0 100644
--- a/vnext/Desktop.DLL/react-native-win32.x86.def
+++ b/vnext/Desktop.DLL/react-native-win32.x86.def
@@ -52,7 +52,6 @@ EXPORTS
 ?makeChakraRuntime@JSI@Microsoft@@YG?AV?$unique_ptr@VRuntime@jsi@facebook@@U?$default_delete@VRuntime@jsi@facebook@@@std@@@std@@$$QAUChakraRuntimeArgs@12@@Z
 ?CreateTimingModule@react@facebook@@YG?AV?$unique_ptr@VCxxModule@module@xplat@facebook@@U?$default_delete@VCxxModule@module@xplat@facebook@@@std@@@std@@ABV?$shared_ptr@VMessageQueueThread@react@facebook@@@4@@Z
 ?Make@IHttpResource@Networking@React@Microsoft@@SG?AV?$shared_ptr@UIHttpResource@Networking@React@Microsoft@@@std@@XZ
-??0NetworkingModule@React@Microsoft@@QAE@XZ
 ?MakeJSQueueThread@ReactNative@Microsoft@@YG?AV?$shared_ptr@VMessageQueueThread@react@facebook@@@std@@XZ
 ?Hash128@SpookyHashV2@hash@folly@@SGXPBXIPA_K1@Z
 ?assertionFailure@detail@folly@@YGXPBD00I0H@Z
diff --git a/vnext/Desktop.IntegrationTests/RNTesterIntegrationTests.cpp b/vnext/Desktop.IntegrationTests/RNTesterIntegrationTests.cpp
index 0813355bf0a..4ed441749b3 100644
--- a/vnext/Desktop.IntegrationTests/RNTesterIntegrationTests.cpp
+++ b/vnext/Desktop.IntegrationTests/RNTesterIntegrationTests.cpp
@@ -27,7 +27,6 @@ TEST_MODULE_INITIALIZE(InitModule) {
 
   SetRuntimeOptionBool("WebSocket.AcceptSelfSigned", true);
   SetRuntimeOptionBool("UseBeastWebSocket", false);
-  SetRuntimeOptionBool("Http.UseMonolithicModule", false);
   SetRuntimeOptionBool("Blob.EnableModule", true);
 
   // WebSocketJSExecutor can't register native log hooks.
diff --git a/vnext/Microsoft.ReactNative/Base/CoreNativeModules.cpp b/vnext/Microsoft.ReactNative/Base/CoreNativeModules.cpp
index c1e1d6dfa9a..bf56183b8e7 100644
--- a/vnext/Microsoft.ReactNative/Base/CoreNativeModules.cpp
+++ b/vnext/Microsoft.ReactNative/Base/CoreNativeModules.cpp
@@ -18,21 +18,6 @@
 
 namespace Microsoft::ReactNative {
 
-using winrt::Microsoft::ReactNative::ReactPropertyBag;
-
-namespace {
-
-using winrt::Microsoft::ReactNative::ReactPropertyId;
-
-ReactPropertyId<bool> HttpUseMonolithicModuleProperty() noexcept {
-  static ReactPropertyId<bool> propId{
-      L"ReactNative.Http"
-      L"UseMonolithicModule"};
-  return propId;
-}
-
-} // namespace
-
 std::vector<facebook::react::NativeModuleDescription> GetCoreModules(
     const std::shared_ptr<facebook::react::MessageQueueThread> &batchingUIMessageQueue,
     const std::shared_ptr<facebook::react::MessageQueueThread>
@@ -45,17 +30,15 @@ std::vector<facebook::react::NativeModuleDescription> GetCoreModules(
       [props = context->Properties()]() { return Microsoft::React::CreateHttpModule(props); },
       jsMessageQueue);
 
-  if (!ReactPropertyBag(context->Properties()).Get(HttpUseMonolithicModuleProperty())) {
-    modules.emplace_back(
-        Microsoft::React::GetBlobModuleName(),
-        [props = context->Properties()]() { return Microsoft::React::CreateBlobModule(props); },
-        batchingUIMessageQueue);
+  modules.emplace_back(
+      Microsoft::React::GetBlobModuleName(),
+      [props = context->Properties()]() { return Microsoft::React::CreateBlobModule(props); },
+      batchingUIMessageQueue);
 
-    modules.emplace_back(
-        Microsoft::React::GetFileReaderModuleName(),
-        [props = context->Properties()]() { return Microsoft::React::CreateFileReaderModule(props); },
-        batchingUIMessageQueue);
-  }
+  modules.emplace_back(
+      Microsoft::React::GetFileReaderModuleName(),
+      [props = context->Properties()]() { return Microsoft::React::CreateFileReaderModule(props); },
+      batchingUIMessageQueue);
 
   // AsyncStorageModule doesn't work without package identity (it indirectly depends on
   // Windows.Storage.StorageFile), so check for package identity before adding it.
diff --git a/vnext/Shared/OInstance.cpp b/vnext/Shared/OInstance.cpp
index 5a93e1bc1e8..d1bb5661a18 100644
--- a/vnext/Shared/OInstance.cpp
+++ b/vnext/Shared/OInstance.cpp
@@ -27,7 +27,6 @@
 
 #include <Modules/ExceptionsManagerModule.h>
 #include <Modules/HttpModule.h>
-#include <Modules/NetworkingModule.h>
 #include <Modules/PlatformConstantsModule.h>
 #include <Modules/SourceCodeModule.h>
 #include <Modules/StatusBarManagerModule.h>
@@ -75,11 +74,7 @@ namespace Microsoft::React {
 
 /*extern*/ std::unique_ptr<facebook::xplat::module::CxxModule> CreateHttpModule(
     winrt::Windows::Foundation::IInspectable const &inspectableProperties) noexcept {
-  if (GetRuntimeOptionBool("Http.UseMonolithicModule")) {
-    return std::make_unique<NetworkingModule>();
-  } else {
-    return std::make_unique<HttpModule>(inspectableProperties);
-  }
+  return std::make_unique<HttpModule>(inspectableProperties);
 }
 
 } // namespace Microsoft::React
@@ -643,8 +638,7 @@ std::vector<std::unique_ptr<NativeModule>> InstanceImpl::GetDefaultNativeModules
   // If this code is enabled, we will have unused module instances.
   // Also, MSRN has a different property bag mechanism incompatible with this method's transitionalProps variable.
 #if (defined(_MSC_VER) && !defined(WINRT))
-  if (Microsoft::React::GetRuntimeOptionBool("Blob.EnableModule") &&
-      !Microsoft::React::GetRuntimeOptionBool("Http.UseMonolithicModule")) {
+  if (Microsoft::React::GetRuntimeOptionBool("Blob.EnableModule")) {
     modules.push_back(std::make_unique<CxxNativeModule>(
         m_innerInstance,
         Microsoft::React::GetBlobModuleName(),
diff --git a/vnext/Shared/Shared.vcxitems b/vnext/Shared/Shared.vcxitems
index 8788faecf59..a7eff112749 100644
--- a/vnext/Shared/Shared.vcxitems
+++ b/vnext/Shared/Shared.vcxitems
@@ -50,7 +50,9 @@
     <ClCompile Include="$(MSBuildThisFileDirectory)Modules\FileReaderModule.cpp" />
     <ClCompile Include="$(MSBuildThisFileDirectory)Modules\HttpModule.cpp" />
     <ClCompile Include="$(MSBuildThisFileDirectory)Modules\I18nModule.cpp" />
-    <ClCompile Include="$(MSBuildThisFileDirectory)Modules\NetworkingModule.cpp" />
+    <ClCompile Include="$(MSBuildThisFileDirectory)Modules\NetworkingModule.cpp">
+      <ExcludedFromBuild>true</ExcludedFromBuild>
+    </ClCompile>
     <ClCompile Include="$(MSBuildThisFileDirectory)Modules\PlatformConstantsModule.cpp" />
     <ClCompile Include="$(MSBuildThisFileDirectory)Modules\SourceCodeModule.cpp" />
     <ClCompile Include="$(MSBuildThisFileDirectory)Modules\StatusBarManagerModule.cpp" />