diff --git a/change/react-native-windows-11865dea-8398-4e1a-a61a-810a133391ee.json b/change/react-native-windows-11865dea-8398-4e1a-a61a-810a133391ee.json
new file mode 100644
index 00000000000..b7e34cd65d8
--- /dev/null
+++ b/change/react-native-windows-11865dea-8398-4e1a-a61a-810a133391ee.json
@@ -0,0 +1,7 @@
+{
+  "type": "patch",
+  "comment": "Use Boost GUID generator (#11470)",
+  "packageName": "react-native-windows",
+  "email": "julio.rocha@microsoft.com",
+  "dependentChangeType": "patch"
+}
diff --git a/vnext/Microsoft.ReactNative.Managed.UnitTests/packages.lock.json b/vnext/Microsoft.ReactNative.Managed.UnitTests/packages.lock.json
index dec34f0ba84..b17b6e4f7b6 100644
--- a/vnext/Microsoft.ReactNative.Managed.UnitTests/packages.lock.json
+++ b/vnext/Microsoft.ReactNative.Managed.UnitTests/packages.lock.json
@@ -98,6 +98,11 @@
           "Microsoft.NETCore.Platforms": "1.1.0"
         }
       },
+      "ReactNative.Hermes.Windows": {
+        "type": "Transitive",
+        "resolved": "0.0.0-2302.1002-2d4bf1df",
+        "contentHash": "4skpllUPEBkww7FN7iacP7NWrZlEGDNg83qIuFjKn4Sl8JpJQZqfUTrXcvh6tb4mHXkmwFoKhLw4Rc5Op7f+8w=="
+      },
       "runtime.win10-arm.Microsoft.Net.Native.Compiler": {
         "type": "Transitive",
         "resolved": "2.2.7-rel-27913-00",
@@ -300,14 +305,13 @@
       "microsoft.reactnative": {
         "type": "Project",
         "dependencies": {
-          "Common": "1.0.0",
-          "Folly": "1.0.0",
-          "Microsoft.UI.Xaml": "2.7.0",
-          "Microsoft.Windows.CppWinRT": "2.0.211028.7",
-          "Microsoft.Windows.SDK.BuildTools": "10.0.22000.194",
-          "ReactCommon": "1.0.0",
-          "ReactNative.Hermes.Windows": "0.11.0-ms.6",
-          "boost": "1.76.0"
+          "Common": "[1.0.0, )",
+          "Folly": "[1.0.0, )",
+          "Microsoft.UI.Xaml": "[2.7.0, )",
+          "Microsoft.Windows.SDK.BuildTools": "[10.0.22000.194, )",
+          "ReactCommon": "[1.0.0, )",
+          "ReactNative.Hermes.Windows": "[0.0.0-2302.1002-2d4bf1df, )",
+          "boost": "[1.76.0, )"
         }
       },
       "microsoft.reactnative.managed": {
diff --git a/vnext/Microsoft.ReactNative.Managed/packages.lock.json b/vnext/Microsoft.ReactNative.Managed/packages.lock.json
index decd73cbdce..9935ddff537 100644
--- a/vnext/Microsoft.ReactNative.Managed/packages.lock.json
+++ b/vnext/Microsoft.ReactNative.Managed/packages.lock.json
@@ -90,8 +90,8 @@
       },
       "ReactNative.Hermes.Windows": {
         "type": "Transitive",
-        "resolved": "0.11.0-ms.6",
-        "contentHash": "WAVLsSZBV4p/3hNC3W67su7xu3f/ZMSKxu0ON7g2GaKRbkJmH0Qyif1IlzcJwtvR48kuOdfgPu7Bgtz3AY+gqg=="
+        "resolved": "0.0.0-2302.1002-2d4bf1df",
+        "contentHash": "4skpllUPEBkww7FN7iacP7NWrZlEGDNg83qIuFjKn4Sl8JpJQZqfUTrXcvh6tb4mHXkmwFoKhLw4Rc5Op7f+8w=="
       },
       "runtime.win10-arm.Microsoft.Net.Native.Compiler": {
         "type": "Transitive",
@@ -176,14 +176,13 @@
       "microsoft.reactnative": {
         "type": "Project",
         "dependencies": {
-          "Common": "1.0.0",
-          "Folly": "1.0.0",
-          "Microsoft.UI.Xaml": "2.7.0",
-          "Microsoft.Windows.CppWinRT": "2.0.211028.7",
-          "Microsoft.Windows.SDK.BuildTools": "10.0.22000.194",
-          "ReactCommon": "1.0.0",
-          "ReactNative.Hermes.Windows": "0.11.0-ms.6",
-          "boost": "1.76.0"
+          "Common": "[1.0.0, )",
+          "Folly": "[1.0.0, )",
+          "Microsoft.UI.Xaml": "[2.7.0, )",
+          "Microsoft.Windows.SDK.BuildTools": "[10.0.22000.194, )",
+          "ReactCommon": "[1.0.0, )",
+          "ReactNative.Hermes.Windows": "[0.0.0-2302.1002-2d4bf1df, )",
+          "boost": "[1.76.0, )"
         }
       },
       "reactcommon": {
diff --git a/vnext/Shared/Modules/BlobModule.cpp b/vnext/Shared/Modules/BlobModule.cpp
index 867e45c0193..10ef4472e8e 100644
--- a/vnext/Shared/Modules/BlobModule.cpp
+++ b/vnext/Shared/Modules/BlobModule.cpp
@@ -12,6 +12,9 @@
 // React Native
 #include <cxxreact/JsArgumentHelpers.h>
 
+// Boost Libriaries
+#include <boost/uuid/uuid_io.hpp>
+
 // Windows API
 #include <winrt/Windows.Foundation.h>
 #include <winrt/Windows.Security.Cryptography.h>
@@ -33,7 +36,6 @@ using winrt::Microsoft::ReactNative::IReactPropertyBag;
 using winrt::Microsoft::ReactNative::ReactNonAbiValue;
 using winrt::Microsoft::ReactNative::ReactPropertyBag;
 using winrt::Microsoft::ReactNative::ReactPropertyId;
-using winrt::Windows::Foundation::GuidHelper;
 using winrt::Windows::Foundation::IInspectable;
 using winrt::Windows::Foundation::Uri;
 using winrt::Windows::Security::Cryptography::CryptographicBuffer;
@@ -249,8 +251,7 @@ void MemoryBlobPersistor::StoreMessage(vector<uint8_t> &&message, string &&blobI
 }
 
 string MemoryBlobPersistor::StoreMessage(vector<uint8_t> &&message) noexcept {
-  // substr(1, 36) strips curly braces from a GUID.
-  auto blobId = winrt::to_string(winrt::to_hstring(GuidHelper::CreateNewGuid())).substr(1, 36);
+  auto blobId = boost::uuids::to_string(m_guidGenerator());
 
   scoped_lock lock{m_mutex};
   m_blobs.insert_or_assign(blobId, std::move(message));
diff --git a/vnext/Shared/Modules/BlobModule.h b/vnext/Shared/Modules/BlobModule.h
index 76c5d46e5e7..900bf5c5d18 100644
--- a/vnext/Shared/Modules/BlobModule.h
+++ b/vnext/Shared/Modules/BlobModule.h
@@ -11,6 +11,9 @@
 // React Native
 #include <cxxreact/CxxModule.h>
 
+// Boost Libraries
+#include <boost/uuid/uuid_generators.hpp>
+
 // Windows API
 #include <winrt/base.h>
 
@@ -26,6 +29,7 @@ namespace Microsoft::React {
 class MemoryBlobPersistor final : public IBlobPersistor {
   std::unordered_map<std::string, std::vector<uint8_t>> m_blobs;
   std::mutex m_mutex;
+  boost::uuids::random_generator m_guidGenerator;
 
  public:
 #pragma region IBlobPersistor