diff --git a/change/react-native-windows-2d37aae0-3bb6-4f89-8428-11cefbabf3b5.json b/change/react-native-windows-2d37aae0-3bb6-4f89-8428-11cefbabf3b5.json
new file mode 100644
index 00000000000..84f9578f0f5
--- /dev/null
+++ b/change/react-native-windows-2d37aae0-3bb6-4f89-8428-11cefbabf3b5.json
@@ -0,0 +1,7 @@
+{
+  "type": "prerelease",
+  "comment": "Use TurboModules for networking in MSRN",
+  "packageName": "react-native-windows",
+  "email": "julio.rocha@microsoft.com",
+  "dependentChangeType": "patch"
+}
diff --git a/vnext/Microsoft.ReactNative/Base/CoreNativeModules.cpp b/vnext/Microsoft.ReactNative/Base/CoreNativeModules.cpp
deleted file mode 100644
index e7cdc886edb..00000000000
--- a/vnext/Microsoft.ReactNative/Base/CoreNativeModules.cpp
+++ /dev/null
@@ -1,44 +0,0 @@
-// Copyright (c) Microsoft Corporation.
-// Licensed under the MIT License.
-
-#include "pch.h"
-#include "CoreNativeModules.h"
-
-// Modules
-#include <AppModelHelpers.h>
-#include <Modules/ClipboardModule.h>
-#include <Modules/NativeUIManager.h>
-#include <Modules/PaperUIManagerModule.h>
-#include <Threading/MessageQueueThreadFactory.h>
-
-// Shared
-#include <CreateModules.h>
-
-namespace Microsoft::ReactNative {
-
-std::vector<facebook::react::NativeModuleDescription> GetCoreModules(
-    const std::shared_ptr<facebook::react::MessageQueueThread> &batchingUIMessageQueue,
-    const std::shared_ptr<facebook::react::MessageQueueThread>
-        &jsMessageQueue, // JS engine thread (what we use for external modules)
-    Mso::CntPtr<Mso::React::IReactContext> &&context) noexcept {
-  std::vector<facebook::react::NativeModuleDescription> modules;
-
-  modules.emplace_back(
-      "Networking",
-      [props = context->Properties()]() { return Microsoft::React::CreateHttpModule(props); },
-      jsMessageQueue);
-
-  modules.emplace_back(
-      Microsoft::React::GetBlobModuleName(),
-      [props = context->Properties()]() { return Microsoft::React::CreateBlobModule(props); },
-      batchingUIMessageQueue);
-
-  modules.emplace_back(
-      Microsoft::React::GetFileReaderModuleName(),
-      [props = context->Properties()]() { return Microsoft::React::CreateFileReaderModule(props); },
-      batchingUIMessageQueue);
-
-  return modules;
-}
-
-} // namespace Microsoft::ReactNative
diff --git a/vnext/Microsoft.ReactNative/Base/CoreNativeModules.h b/vnext/Microsoft.ReactNative/Base/CoreNativeModules.h
deleted file mode 100644
index 19533574515..00000000000
--- a/vnext/Microsoft.ReactNative/Base/CoreNativeModules.h
+++ /dev/null
@@ -1,30 +0,0 @@
-// Copyright (c) Microsoft Corporation.
-// Licensed under the MIT License.
-
-#pragma once
-
-#include <React.h>
-#include <Shared/NativeModuleProvider.h>
-#include <smartPtr/cntPtr.h>
-#include <memory>
-#include <vector>
-
-namespace facebook::react {
-class AppState;
-struct DevSettings;
-class IUIManager;
-class MessageQueueThread;
-} // namespace facebook::react
-
-namespace Microsoft::ReactNative {
-
-struct DeviceInfo;
-struct IReactInstance;
-struct ViewManagerProvider;
-
-std::vector<facebook::react::NativeModuleDescription> GetCoreModules(
-    const std::shared_ptr<facebook::react::MessageQueueThread> &batchingUIMessageQueue,
-    const std::shared_ptr<facebook::react::MessageQueueThread> &jsMessageQueue,
-    Mso::CntPtr<Mso::React::IReactContext> &&context) noexcept;
-
-} // namespace Microsoft::ReactNative
diff --git a/vnext/Microsoft.ReactNative/Microsoft.ReactNative.vcxproj b/vnext/Microsoft.ReactNative/Microsoft.ReactNative.vcxproj
index f42ba04b5d0..8ed10fc993b 100644
--- a/vnext/Microsoft.ReactNative/Microsoft.ReactNative.vcxproj
+++ b/vnext/Microsoft.ReactNative/Microsoft.ReactNative.vcxproj
@@ -185,7 +185,6 @@
   <ItemGroup>
     <ClInclude Include="ABICxxModule.h" />
     <ClInclude Include="ABIViewManager.h" />
-    <ClInclude Include="Base\CoreNativeModules.h" />
     <ClInclude Include="Base\CxxReactIncludes.h" />
     <ClInclude Include="Base\FollyIncludes.h" />
     <ClInclude Include="CoreAppPage.h">
@@ -421,7 +420,6 @@
   <ItemGroup>
     <ClCompile Include="ABICxxModule.cpp" />
     <ClCompile Include="ABIViewManager.cpp" />
-    <ClCompile Include="Base\CoreNativeModules.cpp" />
     <ClCompile Include="Base\CoreUIManagers.cpp" />
     <ClCompile Include="CoreAppPage.cpp">
       <DependentUpon>CoreAppPage.xaml</DependentUpon>
@@ -679,4 +677,4 @@
       </ClCompile>
     </ItemGroup>
   </Target>
-</Project>
+</Project>
\ No newline at end of file
diff --git a/vnext/Microsoft.ReactNative/Microsoft.ReactNative.vcxproj.filters b/vnext/Microsoft.ReactNative/Microsoft.ReactNative.vcxproj.filters
index 02e9b6b23f3..f6e44c0e498 100644
--- a/vnext/Microsoft.ReactNative/Microsoft.ReactNative.vcxproj.filters
+++ b/vnext/Microsoft.ReactNative/Microsoft.ReactNative.vcxproj.filters
@@ -15,9 +15,6 @@
     <ClCompile Include="ReactSupport.cpp" />
     <ClCompile Include="TestHook.cpp" />
     <ClCompile Include="ViewManagersProvider.cpp" />
-    <ClCompile Include="Base\CoreNativeModules.cpp">
-      <Filter>Base</Filter>
-    </ClCompile>
     <ClCompile Include="Base\CoreUIManagers.cpp">
       <Filter>Base</Filter>
     </ClCompile>
@@ -357,9 +354,6 @@
     <ClInclude Include="RedBox.h" />
     <ClInclude Include="TestHook.h" />
     <ClInclude Include="ViewManagersProvider.h" />
-    <ClInclude Include="Base\CoreNativeModules.h">
-      <Filter>Base</Filter>
-    </ClInclude>
     <ClInclude Include="Modules\AccessibilityInfoModule.h">
       <Filter>Modules</Filter>
     </ClInclude>
@@ -632,7 +626,6 @@
     <ClInclude Include="Views\IXamlRootView.h">
       <Filter>Views</Filter>
     </ClInclude>
-    <ClInclude Include="JsiApi.h" />
     <ClInclude Include="RedBoxErrorInfo.h" />
     <ClInclude Include="RedBoxErrorFrameInfo.h" />
     <ClInclude Include="Views\Image\Effects.h">
diff --git a/vnext/Microsoft.ReactNative/ReactHost/ReactInstanceWin.cpp b/vnext/Microsoft.ReactNative/ReactHost/ReactInstanceWin.cpp
index 5a80b6c3bc2..ab038acd916 100644
--- a/vnext/Microsoft.ReactNative/ReactHost/ReactInstanceWin.cpp
+++ b/vnext/Microsoft.ReactNative/ReactHost/ReactInstanceWin.cpp
@@ -6,7 +6,6 @@
 #include "MsoUtils.h"
 
 #include <AppModelHelpers.h>
-#include <Base/CoreNativeModules.h>
 #include <Threading/MessageDispatchQueue.h>
 #include <Threading/MessageQueueThreadFactory.h>
 #include <appModel.h>
@@ -30,7 +29,6 @@
 #include <QuirkSettings.h>
 #include <Shared/DevServerHelper.h>
 #include <Views/ViewManager.h>
-#include <base/CoreNativeModules.h>
 #include <dispatchQueue/dispatchQueue.h>
 #include "DynamicWriter.h"
 #ifndef CORE_ABI
@@ -86,6 +84,7 @@
 #include <tuple>
 #include "ChakraRuntimeHolder.h"
 
+#include <CreateModules.h>
 #include <Utils/Helpers.h>
 #include "CrashManager.h"
 #include "JsiApi.h"
@@ -392,6 +391,16 @@ void ReactInstanceWin::LoadModules(
   registerTurboModule(
       L"Timing", winrt::Microsoft::ReactNative::MakeTurboModuleProvider<::Microsoft::ReactNative::Timing>());
 #endif
+
+  registerTurboModule(::Microsoft::React::GetBlobTurboModuleName(), ::Microsoft::React::GetBlobModuleProvider());
+
+  registerTurboModule(::Microsoft::React::GetHttpTurboModuleName(), ::Microsoft::React::GetHttpModuleProvider());
+
+  registerTurboModule(
+      ::Microsoft::React::GetFileReaderTurboModuleName(), ::Microsoft::React::GetFileReaderModuleProvider());
+
+  registerTurboModule(
+      ::Microsoft::React::GetWebSocketTurboModuleName(), ::Microsoft::React::GetWebSocketModuleProvider());
 }
 
 //! Initialize() is called from the native queue.
@@ -459,15 +468,7 @@ void ReactInstanceWin::Initialize() noexcept {
             }
           };
 
-#ifdef CORE_ABI
           std::vector<facebook::react::NativeModuleDescription> cxxModules;
-#else
-          // Acquire default modules and then populate with custom modules.
-          // Note that some of these have custom thread affinity.
-          std::vector<facebook::react::NativeModuleDescription> cxxModules =
-              Microsoft::ReactNative::GetCoreModules(m_batchingUIThread, m_jsMessageThread.Load(), m_reactContext);
-#endif
-
           auto nmp = std::make_shared<winrt::Microsoft::ReactNative::NativeModulesProvider>();
 
           LoadModules(nmp, m_options.TurboModuleProvider);
diff --git a/vnext/Shared/CreateModules.h b/vnext/Shared/CreateModules.h
index 535f26e0273..2bc4ed8abfe 100644
--- a/vnext/Shared/CreateModules.h
+++ b/vnext/Shared/CreateModules.h
@@ -5,7 +5,6 @@
 
 // React Native
 #include <cxxreact/CxxModule.h>
-#include <smartPtr/cntPtr.h>
 
 // Windows API
 #include <winrt/Windows.Foundation.h>
@@ -14,12 +13,16 @@
 #include <memory>
 
 // Forward declarations. Desktop projects can not access <React.h>
+namespace winrt::Microsoft::ReactNative {
+struct ReactContext;
+struct ReactModuleProvider;
+} // namespace winrt::Microsoft::ReactNative
+
 namespace Mso::React {
 struct IReactContext;
 }
 
-namespace facebook {
-namespace react {
+namespace facebook::react {
 
 class MessageQueueThread;
 
@@ -29,11 +32,12 @@ class MessageQueueThread;
 extern std::unique_ptr<facebook::xplat::module::CxxModule> CreateTimingModule(
     const std::shared_ptr<facebook::react::MessageQueueThread> &nativeThread) noexcept;
 
-} // namespace react
-} // namespace facebook
+} // namespace facebook::react
 
 namespace Microsoft::React {
 
+#pragma region CxxModules
+
 extern const char *GetHttpModuleName() noexcept;
 extern std::unique_ptr<facebook::xplat::module::CxxModule> CreateHttpModule(
     winrt::Windows::Foundation::IInspectable const &inspectableProperties) noexcept;
@@ -50,4 +54,22 @@ extern const char *GetFileReaderModuleName() noexcept;
 extern std::unique_ptr<facebook::xplat::module::CxxModule> CreateFileReaderModule(
     winrt::Windows::Foundation::IInspectable const &inspectableProperties) noexcept;
 
+#pragma endregion CxxModules
+
+#pragma region TurboModules
+
+extern const wchar_t *GetBlobTurboModuleName() noexcept;
+extern const winrt::Microsoft::ReactNative::ReactModuleProvider &GetBlobModuleProvider() noexcept;
+
+extern const wchar_t *GetHttpTurboModuleName() noexcept;
+extern const winrt::Microsoft::ReactNative::ReactModuleProvider &GetHttpModuleProvider() noexcept;
+
+extern const wchar_t *GetFileReaderTurboModuleName() noexcept;
+extern const winrt::Microsoft::ReactNative::ReactModuleProvider &GetFileReaderModuleProvider() noexcept;
+
+extern const wchar_t *GetWebSocketTurboModuleName() noexcept;
+extern const winrt::Microsoft::ReactNative::ReactModuleProvider &GetWebSocketModuleProvider() noexcept;
+
+#pragma endregion TurboModules
+
 } // namespace Microsoft::React
diff --git a/vnext/Shared/Modules/BlobModule.cpp b/vnext/Shared/Modules/BlobModule.cpp
index d76a462c670..4750d3e58a1 100644
--- a/vnext/Shared/Modules/BlobModule.cpp
+++ b/vnext/Shared/Modules/BlobModule.cpp
@@ -3,6 +3,7 @@
 
 #include "BlobModule.h"
 
+#include <CreateModules.h>
 #include <Modules/CxxModuleUtilities.h>
 
 // React Native
@@ -20,8 +21,12 @@ namespace msrn = winrt::Microsoft::ReactNative;
 
 namespace {
 constexpr char s_moduleName[] = "BlobModule";
+constexpr wchar_t s_moduleNameW[] = L"BlobModule";
 
 const auto &blobKeys = IBlobResource::FieldNames();
+
+msrn::ReactModuleProvider s_moduleProvider = msrn::MakeTurboModuleProvider<Microsoft::React::BlobTurboModule>();
+
 } // namespace
 
 namespace Microsoft::React {
@@ -156,4 +161,12 @@ vector<module::CxxModule::Method> BlobModule::getMethods() {
   return nullptr;
 }
 
+/*extern*/ const wchar_t *GetBlobTurboModuleName() noexcept {
+  return s_moduleNameW;
+}
+
+/*extern*/ const msrn::ReactModuleProvider &GetBlobModuleProvider() noexcept {
+  return s_moduleProvider;
+}
+
 } // namespace Microsoft::React
diff --git a/vnext/Shared/Modules/FileReaderModule.cpp b/vnext/Shared/Modules/FileReaderModule.cpp
index 19a2910be34..09db7bdd4fd 100644
--- a/vnext/Shared/Modules/FileReaderModule.cpp
+++ b/vnext/Shared/Modules/FileReaderModule.cpp
@@ -3,6 +3,7 @@
 
 #include "FileReaderModule.h"
 
+#include <CreateModules.h>
 #include <ReactPropertyBag.h>
 #include <sstream>
 
@@ -28,6 +29,9 @@ using winrt::Windows::Foundation::IInspectable;
 
 namespace {
 constexpr char s_moduleName[] = "FileReaderModule";
+constexpr wchar_t s_moduleNameW[] = L"FileReaderModule";
+
+msrn::ReactModuleProvider s_moduleProvider = msrn::MakeTurboModuleProvider<Microsoft::React::FileReaderTurboModule>();
 } // namespace
 
 namespace Microsoft::React {
@@ -198,4 +202,12 @@ void FileReaderTurboModule::ReadAsText(
   return nullptr;
 }
 
+/*extern*/ const wchar_t *GetFileReaderTurboModuleName() noexcept {
+  return s_moduleNameW;
+}
+
+/*extern*/ const msrn::ReactModuleProvider &GetFileReaderModuleProvider() noexcept {
+  return s_moduleProvider;
+}
+
 } // namespace Microsoft::React
diff --git a/vnext/Shared/Modules/HttpModule.cpp b/vnext/Shared/Modules/HttpModule.cpp
index cab864e3d33..f3941b31e40 100644
--- a/vnext/Shared/Modules/HttpModule.cpp
+++ b/vnext/Shared/Modules/HttpModule.cpp
@@ -5,6 +5,7 @@
 
 #include "HttpModule.h"
 
+#include <CreateModules.h>
 #include <Modules/CxxModuleUtilities.h>
 #include <ReactPropertyBag.h>
 
@@ -32,6 +33,7 @@ using Microsoft::React::Modules::SendEvent;
 using Microsoft::React::Networking::IHttpResource;
 
 constexpr char s_moduleName[] = "Networking";
+constexpr wchar_t s_moduleNameW[] = L"Networking";
 
 // React event names
 constexpr char completedResponse[] = "didCompleteNetworkResponse";
@@ -48,6 +50,8 @@ constexpr wchar_t receivedIncrementalDataW[] = L"didReceiveNetworkIncrementalDat
 constexpr wchar_t receivedDataProgressW[] = L"didReceiveNetworkDataProgress";
 constexpr wchar_t receivedDataW[] = L"didReceiveNetworkData";
 
+msrn::ReactModuleProvider s_moduleProvider = msrn::MakeTurboModuleProvider<Microsoft::React::HttpTurboModule>();
+
 static void SetUpHttpResource(
     shared_ptr<IHttpResource> resource,
     weak_ptr<Instance> weakReactInstance,
@@ -327,4 +331,12 @@ std::vector<facebook::xplat::module::CxxModule::Method> HttpModule::getMethods()
   return s_moduleName;
 }
 
+/*extern*/ const wchar_t *GetHttpTurboModuleName() noexcept {
+  return s_moduleNameW;
+}
+
+/*extern*/ const msrn::ReactModuleProvider &GetHttpModuleProvider() noexcept {
+  return s_moduleProvider;
+}
+
 } // namespace Microsoft::React
diff --git a/vnext/Shared/Modules/WebSocketModule.cpp b/vnext/Shared/Modules/WebSocketModule.cpp
index f53b62e5321..5d572d84e46 100644
--- a/vnext/Shared/Modules/WebSocketModule.cpp
+++ b/vnext/Shared/Modules/WebSocketModule.cpp
@@ -6,6 +6,7 @@
 #include <Modules/WebSocketModule.h>
 #include <Modules/WebSocketTurboModule.h>
 
+#include <CreateModules.h>
 #include <Modules/CxxModuleUtilities.h>
 #include <Modules/IWebSocketModuleContentHandler.h>
 #include <ReactPropertyBag.h>
@@ -50,6 +51,9 @@ using Microsoft::React::Modules::SendEvent;
 using Microsoft::React::Networking::IWebSocketResource;
 
 constexpr char s_moduleName[] = "WebSocketModule";
+constexpr wchar_t s_moduleNameW[] = L"WebSocketModule";
+
+msrn::ReactModuleProvider s_moduleProvider = msrn::MakeTurboModuleProvider<Microsoft::React::WebSocketTurboModule>();
 
 static shared_ptr<IWebSocketResource>
 GetOrCreateWebSocket(int64_t id, string &&url, weak_ptr<WebSocketModule::SharedState> weakState) {
@@ -495,4 +499,12 @@ void WebSocketTurboModule::RemoveListeners(double /*count*/) noexcept {}
   return nullptr;
 }
 
+/*extern*/ const wchar_t *GetWebSocketTurboModuleName() noexcept {
+  return s_moduleNameW;
+}
+
+/*extern*/ const msrn::ReactModuleProvider &GetWebSocketModuleProvider() noexcept {
+  return s_moduleProvider;
+}
+
 } // namespace Microsoft::React