diff --git a/packages/E2ETest/wdio/test/DirectManipulation.spec.ts b/packages/E2ETest/wdio/test/DirectManipulation.spec.ts
index 6e97bb96599..bc609af6a41 100644
--- a/packages/E2ETest/wdio/test/DirectManipulation.spec.ts
+++ b/packages/E2ETest/wdio/test/DirectManipulation.spec.ts
@@ -28,9 +28,6 @@ describe('DirectManipulationTest', () => {
       result.includes('width=50'),
       'measureLayout response has correct width'
     );
-    // https://github.com/microsoft/react-native-windows/issues/4122
-    // Un-comment this when bug 4122 is fixed
-    // E2ETEST_OVERRIDE_4122
-    // assert.ok(result.includes('x=20;'), 'measureLayout response x=20');
+    assert.ok(result.includes('x=20;'), 'measureLayout response x=20');
   });
 });
diff --git a/packages/E2ETest/windows/ReactUWPTestApp/App.xaml.cs b/packages/E2ETest/windows/ReactUWPTestApp/App.xaml.cs
index 0a6a8c61fd0..d813eb85f37 100644
--- a/packages/E2ETest/windows/ReactUWPTestApp/App.xaml.cs
+++ b/packages/E2ETest/windows/ReactUWPTestApp/App.xaml.cs
@@ -56,12 +56,6 @@ protected override void OnLaunched(LaunchActivatedEventArgs e)
             base.OnLaunched(e);
             SystemNavigationManager.GetForCurrentView().AppViewBackButtonVisibility = AppViewBackButtonVisibility.Collapsed;
             ApplicationView.GetForCurrentView().TryResizeView(new Size(800, 600));
-#if !E2ETEST_OVERRIDE_4122
-#error [E2ETest] - There is a bug in Yoga with v142/VS2019 that makes the masters for this app different in Release|x64 than in other platforms.
-#error However we want to test what people will be shipping. As a result, the tree dump output won't match the masters (which have the bug).
-#error You can disable this warning by defining the constant E2ETEST_OVERRIDE_4122 in the project properties page under "Define Constants"
-#error For more information see https://github.com/microsoft/react-native-windows/issues/4122
-#endif
             if (DisplayInformation.GetForCurrentView().ResolutionScale != ResolutionScale.Scale100Percent)
             {
                 throw new Exception("A bug requires this app to run at 100% for accurate results - See https://github.com/microsoft/react-native-windows/issues/4619");
diff --git a/packages/E2ETest/windows/ReactUWPTestApp/ReactUWPTestApp.csproj b/packages/E2ETest/windows/ReactUWPTestApp/ReactUWPTestApp.csproj
index 6611c1e40c4..07275254969 100644
--- a/packages/E2ETest/windows/ReactUWPTestApp/ReactUWPTestApp.csproj
+++ b/packages/E2ETest/windows/ReactUWPTestApp/ReactUWPTestApp.csproj
@@ -81,7 +81,7 @@
   </PropertyGroup>
   <PropertyGroup Condition="'$(Configuration)|$(Platform)' == 'Release|x64'">
     <OutputPath>bin\x64\Release\</OutputPath>
-    <DefineConstants>TRACE;NETFX_CORE;WINDOWS_UWP;E2ETEST_OVERRIDE_4122</DefineConstants>
+    <DefineConstants>TRACE;NETFX_CORE;WINDOWS_UWP;</DefineConstants>
     <Optimize>true</Optimize>
     <NoWarn>;2008</NoWarn>
     <DebugType>pdbonly</DebugType>