diff --git a/requirements.txt b/requirements.txt
index ef0e8aee69b..b43644616d2 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -4,7 +4,7 @@ scipy>=1.1.0
 matplotlib
 pyqt5>=5.10,<5.14; platform_system == "Darwin"
 pyqt5>=5.10,!=5.15.2,!=5.15.3; platform_system == "Linux"
-pyqt5>=5.10,!=5.15.3; platform_system != "Linux" and platform_system != "Darwin"
+pyqt5>=5.10,!=5.15.3; platform_system == "Windows"
 pyqt5-sip
 sip
 scikit-learn
diff --git a/setup.py b/setup.py
index b59b4595397..9f72663657b 100644
--- a/setup.py
+++ b/setup.py
@@ -5,9 +5,24 @@
 
 import os
 import os.path as op
+import re
 
 from setuptools import setup
 
+
+def parse_requirements_file(fname):
+    requirements = list()
+    with open(fname, 'r') as fid:
+        for line in fid:
+            req = line.strip()
+            if req.startswith('#'):
+                continue
+            # strip end-of-line comments
+            req = req.split('#', maxsplit=1)[0].strip()
+            requirements.append(req)
+    return requirements
+
+
 # get the version (don't import mne here, so dependencies are not needed)
 version = None
 with open(op.join('mne', '_version.py'), 'r') as fid:
@@ -19,10 +34,8 @@
     raise RuntimeError('Could not determine version')
 
 
-descr = """MNE python project for MEG and EEG data analysis."""
-
 DISTNAME = 'mne'
-DESCRIPTION = descr
+DESCRIPTION = 'MNE-Python project for MEG and EEG data analysis.'
 MAINTAINER = 'Alexandre Gramfort'
 MAINTAINER_EMAIL = 'alexandre.gramfort@inria.fr'
 URL = 'https://mne.tools/dev/'
@@ -49,14 +62,22 @@ def package_tree(pkgroot):
         long_description = fid.read()
 
     hard_dependencies = ('numpy', 'scipy')
+    data_dependencies = ('pooch', 'tqdm')
+    full_install_requires = parse_requirements_file('requirements.txt')
     install_requires = list()
-    with open('requirements.txt', 'r') as fid:
-        for line in fid:
-            req = line.strip()
-            for hard_dep in hard_dependencies:
-                if req.startswith(hard_dep):
-                    install_requires.append(req)
+    data_requires = list()
+    for req in full_install_requires:
+        pkg = re.split(r'[<>=!;]', req, maxsplit=1)[0]
+        if pkg in hard_dependencies:
+            install_requires.append(req)
+        elif pkg in data_dependencies:
+            data_requires.append(req)
+    for req in install_requires:
+        full_install_requires.remove(req)
 
+    doc_requires = parse_requirements_file('requirements_doc.txt')
+    test_requires = (parse_requirements_file('requirements_testing.txt') +
+                     parse_requirements_file('requirements_testing_extra.txt'))
     setup(name=DISTNAME,
           maintainer=MAINTAINER,
           include_package_data=True,
@@ -90,6 +111,12 @@ def package_tree(pkgroot):
           platforms='any',
           python_requires='>=3.7',
           install_requires=install_requires,
+          extras_require={
+              'doc': doc_requires,
+              'data': data_requires,
+              'test': test_requires,
+              'full': full_install_requires
+          },
           packages=package_tree('mne'),
           package_data={'mne': [
               op.join('data', 'eegbci_checksums.txt'),