diff --git a/setup.py b/setup.py
index 0fbece6..e05b33f 100644
--- a/setup.py
+++ b/setup.py
@@ -29,6 +29,7 @@ def read(*parts):
         "Framework :: Django",
         "Framework :: Django :: 3.2",
         "Framework :: Django :: 4.0",
+        "Framework :: Django :: 4.1",
         "Framework :: Flask",
         "Intended Audience :: Developers",
         "License :: OSI Approved :: Mozilla Public License 2.0 (MPL 2.0)",
diff --git a/tests/constraints/django-4.1.txt b/tests/constraints/django-4.1.txt
new file mode 100644
index 0000000..a0aaa8b
--- /dev/null
+++ b/tests/constraints/django-4.1.txt
@@ -0,0 +1 @@
+Django>=4.1,<4.2
diff --git a/tests/constraints/flask-2.2.txt b/tests/constraints/flask-2.2.txt
new file mode 100644
index 0000000..1e7ae79
--- /dev/null
+++ b/tests/constraints/flask-2.2.txt
@@ -0,0 +1 @@
+Flask>=2.2,<2.3
diff --git a/tests/django/settings.py b/tests/django/settings.py
index 875e136..341b3f3 100644
--- a/tests/django/settings.py
+++ b/tests/django/settings.py
@@ -66,3 +66,5 @@
     },
     "loggers": {"request.summary": {"handlers": ["console"], "level": "DEBUG"}},
 }
+
+USE_TZ = True  # Default False until Django 5.0, when it switches to True
diff --git a/tox.ini b/tox.ini
index 378e2a4..b28cbcb 100644
--- a/tox.ini
+++ b/tox.ini
@@ -5,8 +5,8 @@ envlist =
     py38-lint
     py38-docs
     py{37,38,39,310}-dj32
-    py{38,39,310}-dj{40}
-    py{37,38,39,310}-fl{012,10,11,20,21}
+    py{38,39,310}-dj{40,41}
+    py{37,38,39,310}-fl{012,10,11,20,21,22}
     py{37,38,39}-s20
     py{37,38,39,310}-s{21,22}
 
@@ -25,24 +25,26 @@ setenv =
     PYTHONPATH = {toxinidir}
 deps =
     -rtests/requirements/default.txt
-    dj{32,40}: -rtests/requirements/django.txt
-    fl{012,10,11,20,21}: -rtests/requirements/flask.txt
+    dj{32,40,41}: -rtests/requirements/django.txt
+    fl{012,10,11,20,21,22}: -rtests/requirements/flask.txt
     s20: -rtests/requirements/sanic-20.txt
     s{21,22}: -rtests/requirements/sanic.txt
     dj32: -ctests/constraints/django-3.2.txt
     dj40: -ctests/constraints/django-4.0.txt
+    dj41: -ctests/constraints/django-4.1.txt
     fl012: -ctests/constraints/flask-0.12.txt
     fl10: -ctests/constraints/flask-1.0.txt
     fl11: -ctests/constraints/flask-1.1.txt
     fl20: -ctests/constraints/flask-2.0.txt
-    fl21: -ctests/constraints/flask-2.0.txt
+    fl21: -ctests/constraints/flask-2.1.txt
+    fl22: -ctests/constraints/flask-2.2.txt
     s20: -ctests/constraints/sanic-20.txt
     s21: -ctests/constraints/sanic-21.txt
     s22: -ctests/constraints/sanic-22.txt
 commands =
     python --version
-    dj{32,40}: pytest tests/core/ tests/django --nomigrations {posargs:}
-    fl{012,10,11,20,21}: pytest tests/core/ tests/flask/ {posargs:}
+    dj{32,40,41}: pytest tests/core/ tests/django --nomigrations {posargs:}
+    fl{012,10,11,20,21,22}: pytest tests/core/ tests/flask/ {posargs:}
     s{20,21,22}: pytest tests/core/ tests/sanic/ {posargs:}
 
 [testenv:py38-docs]