diff --git a/doc/api/cli.md b/doc/api/cli.md
index fe680b06a3b949..73d8fb3191e3f0 100644
--- a/doc/api/cli.md
+++ b/doc/api/cli.md
@@ -1702,6 +1702,25 @@ changes:
 
 Specify the maximum size, in bytes, of HTTP headers. Defaults to 16 KiB.
 
+### `--max-old-space-size-percentage=percentage`
+
+Sets the maximum memory size of V8's old memory section as a percentage of available system memory.
+This flag takes precedence over `--max-old-space-size` when both are specified.
+
+The `percentage` parameter must be a number greater than 0 and up to 100, representing the percentage
+of available system memory to allocate to the V8 heap.
+
+**Note:** This flag utilizes `--max-old-space-size`, which may be unreliable on 32-bit platforms due to
+integer overflow issues.
+
+```bash
+# Using 50% of available system memory
+node --max-old-space-size-percentage=50 index.js
+
+# Using 75% of available system memory
+node --max-old-space-size-percentage=75 index.js
+```
+
 ### `--napi-modules`
 
 <!-- YAML
@@ -3387,6 +3406,7 @@ one is included in the list below.
 * `--inspect`
 * `--localstorage-file`
 * `--max-http-header-size`
+* `--max-old-space-size-percentage`
 * `--napi-modules`
 * `--network-family-autoselection-attempt-timeout`
 * `--no-addons`
diff --git a/doc/node-config-schema.json b/doc/node-config-schema.json
index b78dfa32aec179..58f316c19a969e 100644
--- a/doc/node-config-schema.json
+++ b/doc/node-config-schema.json
@@ -278,6 +278,9 @@
         "max-http-header-size": {
           "type": "number"
         },
+        "max-old-space-size-percentage": {
+          "type": "string"
+        },
         "network-family-autoselection": {
           "type": "boolean"
         },
diff --git a/doc/node.1 b/doc/node.1
index e3b2c45af01b2e..196545e9d10c2d 100644
--- a/doc/node.1
+++ b/doc/node.1
@@ -346,6 +346,20 @@ The file used to store localStorage data.
 .It Fl -max-http-header-size Ns = Ns Ar size
 Specify the maximum size of HTTP headers in bytes. Defaults to 16 KiB.
 .
+.It Fl -max-old-space-size-percentage Ns = Ns Ar percentage
+Sets the maximum memory size of V8's old memory section as a percentage of available system memory.
+This flag takes precedence over
+.Fl -max-old-space-size
+when both are specified.
+The
+.Ar percentage
+parameter must be a number greater than 0 and up to 100, representing the percentage
+of available system memory to allocate to the V8 heap.
+.Pp
+Note: This flag utilizes
+.Fl -max-old-space-size ,
+which may be unreliable on 32-bit platforms due to integer overflow issues.
+.
 .It Fl -napi-modules
 This option is a no-op.
 It is kept for compatibility.
diff --git a/src/node.cc b/src/node.cc
index d0890e5d77da40..2d8d0000d52411 100644
--- a/src/node.cc
+++ b/src/node.cc
@@ -818,6 +818,13 @@ static ExitCode ProcessGlobalArgsInternal(std::vector<std::string>* args,
   // anymore.
   v8_args.emplace_back("--no-harmony-import-assertions");
 
+  if (!per_process::cli_options->per_isolate->max_old_space_size_percentage
+           .empty()) {
+    v8_args.emplace_back(
+        "--max_old_space_size=" +
+        per_process::cli_options->per_isolate->max_old_space_size);
+  }
+
   auto env_opts = per_process::cli_options->per_isolate->per_env;
   if (std::find(v8_args.begin(), v8_args.end(),
                 "--abort-on-uncaught-exception") != v8_args.end() ||
diff --git a/src/node_options.cc b/src/node_options.cc
index ed85bf11f6f325..e12c3e7790038c 100644
--- a/src/node_options.cc
+++ b/src/node_options.cc
@@ -7,6 +7,7 @@
 #include "node_external_reference.h"
 #include "node_internals.h"
 #include "node_sea.h"
+#include "uv.h"
 #if HAVE_OPENSSL
 #include "openssl/opensslv.h"
 #endif
@@ -14,6 +15,7 @@
 #include <algorithm>
 #include <array>
 #include <charconv>
+#include <cstdint>
 #include <limits>
 #include <sstream>
 #include <string_view>
@@ -103,8 +105,54 @@ void PerProcessOptions::CheckOptions(std::vector<std::string>* errors,
   per_isolate->CheckOptions(errors, argv);
 }
 
+void PerIsolateOptions::HandleMaxOldSpaceSizePercentage(
+    std::vector<std::string>* errors,
+    std::string* max_old_space_size_percentage) {
+  std::string original_input_for_error = *max_old_space_size_percentage;
+  // Parse the percentage value
+  char* end_ptr;
+  double percentage =
+      std::strtod(max_old_space_size_percentage->c_str(), &end_ptr);
+
+  // Validate the percentage value
+  if (*end_ptr != '\0' || percentage <= 0.0 || percentage > 100.0) {
+    errors->push_back("--max-old-space-size-percentage must be greater "
+                      "than 0 and up to 100. Got: " +
+                      original_input_for_error);
+    return;
+  }
+
+  // Get available memory in bytes
+  uint64_t total_memory = uv_get_total_memory();
+  uint64_t constrained_memory = uv_get_constrained_memory();
+
+  // Use constrained memory if available, otherwise use total memory
+  // This logic correctly handles the documented guarantees.
+  // Use uint64_t for the result to prevent data loss on 32-bit systems.
+  uint64_t available_memory =
+      (constrained_memory > 0 && constrained_memory != UINT64_MAX)
+          ? constrained_memory
+          : total_memory;
+
+  if (available_memory == 0) {
+    errors->push_back("the available memory can not be calculated");
+    return;
+  }
+
+  // Convert to MB and calculate the percentage
+  uint64_t memory_mb = available_memory / (1024 * 1024);
+  uint64_t calculated_mb = static_cast<size_t>(memory_mb * percentage / 100.0);
+
+  // Convert back to string
+  max_old_space_size = std::to_string(calculated_mb);
+}
+
 void PerIsolateOptions::CheckOptions(std::vector<std::string>* errors,
                                      std::vector<std::string>* argv) {
+  if (!max_old_space_size_percentage.empty()) {
+    HandleMaxOldSpaceSizePercentage(errors, &max_old_space_size_percentage);
+  }
+
   per_env->CheckOptions(errors, argv);
 }
 
@@ -987,6 +1035,11 @@ PerIsolateOptionsParser::PerIsolateOptionsParser(
             V8Option{},
             kAllowedInEnvvar);
   AddOption("--max-old-space-size", "", V8Option{}, kAllowedInEnvvar);
+  AddOption("--max-old-space-size-percentage",
+            "set V8's max old space size as a percentage of available memory "
+            "(e.g., '50%'). Takes precedence over --max-old-space-size.",
+            &PerIsolateOptions::max_old_space_size_percentage,
+            kAllowedInEnvvar);
   AddOption("--max-semi-space-size", "", V8Option{}, kAllowedInEnvvar);
   AddOption("--perf-basic-prof", "", V8Option{}, kAllowedInEnvvar);
   AddOption(
diff --git a/src/node_options.h b/src/node_options.h
index cdbd9ca39e907a..1339c5077e2a5b 100644
--- a/src/node_options.h
+++ b/src/node_options.h
@@ -283,6 +283,8 @@ class PerIsolateOptions : public Options {
   bool report_uncaught_exception = false;
   bool report_on_signal = false;
   bool experimental_shadow_realm = false;
+  std::string max_old_space_size_percentage;
+  std::string max_old_space_size;
   int64_t stack_trace_limit = 10;
   std::string report_signal = "SIGUSR2";
   bool build_snapshot = false;
@@ -290,6 +292,8 @@ class PerIsolateOptions : public Options {
   inline EnvironmentOptions* get_per_env_options();
   void CheckOptions(std::vector<std::string>* errors,
                     std::vector<std::string>* argv) override;
+  void HandleMaxOldSpaceSizePercentage(std::vector<std::string>* errors,
+                                       std::string* max_old_space_size);
 
   inline std::shared_ptr<PerIsolateOptions> Clone() const;
 
diff --git a/test/parallel/test-max-old-space-size-percentage.js b/test/parallel/test-max-old-space-size-percentage.js
new file mode 100644
index 00000000000000..d4da10b3012662
--- /dev/null
+++ b/test/parallel/test-max-old-space-size-percentage.js
@@ -0,0 +1,143 @@
+'use strict';
+
+// This test validates the --max-old-space-size-percentage flag functionality
+
+const common = require('../common');
+// This flag utilizes --max-old-space-size, which is unreliable on
+// 32-bit platforms due to integer overflow issues.
+common.skipIf32Bits();
+
+const assert = require('node:assert');
+const { spawnSync } = require('child_process');
+const os = require('os');
+
+// Valid cases
+const validPercentages = [
+  '1', '10', '25', '50', '75', '99', '100', '25.5',
+];
+
+// Invalid cases
+const invalidPercentages = [
+  ['', /--max-old-space-size-percentage= requires an argument/],
+  ['0', /--max-old-space-size-percentage must be greater than 0 and up to 100\. Got: 0/],
+  ['101', /--max-old-space-size-percentage must be greater than 0 and up to 100\. Got: 101/],
+  ['-1', /--max-old-space-size-percentage must be greater than 0 and up to 100\. Got: -1/],
+  ['abc', /--max-old-space-size-percentage must be greater than 0 and up to 100\. Got: abc/],
+  ['1%', /--max-old-space-size-percentage must be greater than 0 and up to 100\. Got: 1%/],
+];
+
+// Test valid cases
+validPercentages.forEach((input) => {
+  const result = spawnSync(process.execPath, [
+    `--max-old-space-size-percentage=${input}`,
+  ], { stdio: ['pipe', 'pipe', 'pipe'] });
+  assert.strictEqual(result.status, 0, `Expected exit code 0 for valid input ${input}`);
+  assert.strictEqual(result.stderr.toString(), '', `Expected empty stderr for valid input ${input}`);
+});
+
+// Test invalid cases
+invalidPercentages.forEach((input) => {
+  const result = spawnSync(process.execPath, [
+    `--max-old-space-size-percentage=${input[0]}`,
+  ], { stdio: ['pipe', 'pipe', 'pipe'] });
+  assert.notStrictEqual(result.status, 0, `Expected non-zero exit for invalid input ${input[0]}`);
+  assert(input[1].test(result.stderr.toString()), `Unexpected error message for invalid input ${input[0]}`);
+});
+
+// Test NODE_OPTIONS with valid percentages
+validPercentages.forEach((input) => {
+  const result = spawnSync(process.execPath, [], {
+    stdio: ['pipe', 'pipe', 'pipe'],
+    env: { ...process.env, NODE_OPTIONS: `--max-old-space-size-percentage=${input}` }
+  });
+  assert.strictEqual(result.status, 0, `NODE_OPTIONS: Expected exit code 0 for valid input ${input}`);
+  assert.strictEqual(result.stderr.toString(), '', `NODE_OPTIONS: Expected empty stderr for valid input ${input}`);
+});
+
+// Test NODE_OPTIONS with invalid percentages
+invalidPercentages.forEach((input) => {
+  const result = spawnSync(process.execPath, [], {
+    stdio: ['pipe', 'pipe', 'pipe'],
+    env: { ...process.env, NODE_OPTIONS: `--max-old-space-size-percentage=${input[0]}` }
+  });
+  assert.notStrictEqual(result.status, 0, `NODE_OPTIONS: Expected non-zero exit for invalid input ${input[0]}`);
+  assert(input[1].test(result.stderr.toString()), `NODE_OPTIONS: Unexpected error message for invalid input ${input[0]}`);
+});
+
+// Test percentage calculation validation
+function getHeapSizeForPercentage(percentage) {
+  const result = spawnSync(process.execPath, [
+    '--max-old-space-size=3000', // This value should be ignored, since percentage takes precedence
+    `--max-old-space-size-percentage=${percentage}`,
+    '--max-old-space-size=1000', // This value should be ignored, since percentage take precedence
+    '-e', `
+      const v8 = require('v8');
+      const stats = v8.getHeapStatistics();
+      const heapSizeLimitMB = Math.floor(stats.heap_size_limit / 1024 / 1024);
+      console.log(heapSizeLimitMB);
+    `,
+  ], {
+    stdio: ['pipe', 'pipe', 'pipe'],
+    env: {
+      ...process.env,
+      NODE_OPTIONS: `--max-old-space-size=2000` // This value should be ignored, since percentage takes precedence
+    }
+  });
+
+  if (result.status !== 0) {
+    throw new Error(`Failed to get heap size for ${percentage}: ${result.stderr.toString()}`);
+  }
+
+  return parseInt(result.stdout.toString(), 10);
+}
+
+const testPercentages = [25, 50, 75, 100];
+const heapSizes = {};
+
+// Get heap sizes for all test percentages
+testPercentages.forEach((percentage) => {
+  heapSizes[percentage] = getHeapSizeForPercentage(percentage);
+});
+
+// Test relative relationships between percentages
+// 50% should be roughly half of 100%
+const ratio50to100 = heapSizes[50] / heapSizes[100];
+assert(
+  ratio50to100 >= 0.4 && ratio50to100 <= 0.6,
+  `50% heap size should be roughly half of 100% (got ${ratio50to100.toFixed(2)}, expected ~0.5)`
+);
+
+// 25% should be roughly quarter of 100%
+const ratio25to100 = heapSizes[25] / heapSizes[100];
+assert(
+  ratio25to100 >= 0.15 && ratio25to100 <= 0.35,
+  `25% heap size should be roughly quarter of 100% (got ${ratio25to100.toFixed(2)}, expected ~0.25)`
+);
+
+// 75% should be roughly three-quarters of 100%
+const ratio75to100 = heapSizes[75] / heapSizes[100];
+assert(
+  ratio75to100 >= 0.65 && ratio75to100 <= 0.85,
+  `75% heap size should be roughly three-quarters of 100% (got ${ratio75to100.toFixed(2)}, expected ~0.75)`
+);
+
+// Validate heap sizes against system memory
+const totalMemoryMB = Math.floor(os.totalmem() / 1024 / 1024);
+const uint64Max = 2 ** 64 - 1;
+const constrainedMemory = process.constrainedMemory();
+const constrainedMemoryMB = Math.floor(constrainedMemory / 1024 / 1024);
+const effectiveMemoryMB =
+  constrainedMemory > 0 && constrainedMemory !== uint64Max ? constrainedMemoryMB : totalMemoryMB;
+const margin = 10; // 10% margin
+testPercentages.forEach((percentage) => {
+  const upperLimit = effectiveMemoryMB * ((percentage + margin) / 100);
+  assert(
+    heapSizes[percentage] <= upperLimit,
+    `Heap size for ${percentage}% (${heapSizes[percentage]} MB) should not exceed upper limit (${upperLimit} MB)`
+  );
+  const lowerLimit = effectiveMemoryMB * ((percentage - margin) / 100);
+  assert(
+    heapSizes[percentage] >= lowerLimit,
+    `Heap size for ${percentage}% (${heapSizes[percentage]} MB) should not be less than lower limit (${lowerLimit} MB)`
+  );
+});