diff --git a/lib/internal/modules/cjs/loader.js b/lib/internal/modules/cjs/loader.js
index b8aac380da7974..74e1e8c5227bd3 100644
--- a/lib/internal/modules/cjs/loader.js
+++ b/lib/internal/modules/cjs/loader.js
@@ -1135,6 +1135,11 @@ function defaultLoadImpl(filename, format) {
     case 'module-typescript':
     case 'commonjs-typescript':
     case 'typescript': {
+      const isPipePath = ['/dev/stdin', '/dev/fd/0'].includes(filename) ||
+                         (filename.startsWith('/proc/') && filename.includes('/fd/pipe:'));
+      if (isPipePath) {
+        return fs.readFileSync(0, 'utf8');
+      }
       return fs.readFileSync(filename, 'utf8');
     }
     case 'builtin':
diff --git a/test/parallel/test-typescript-stdin-pipe.js b/test/parallel/test-typescript-stdin-pipe.js
new file mode 100644
index 00000000000000..741fa8c7bbab42
--- /dev/null
+++ b/test/parallel/test-typescript-stdin-pipe.js
@@ -0,0 +1,21 @@
+'use strict';
+const common = require('../common');
+
+if (common.isWindows || common.isAIX || common.isIBMi)
+  common.skip(`No /dev/stdin on ${process.platform}.`);
+
+const assert = require('assert');
+const { exec } = require('child_process');
+
+const tsCode = `
+const message = "JavaScript from pipe";
+console.log(message);
+`;
+
+
+const [cmd, opts] = common.escapePOSIXShell`printf "${tsCode}" | ${process.execPath} /dev/stdin`;
+
+exec(cmd, opts, common.mustSucceed((stdout, stderr) => {
+  assert.strictEqual(stdout.trim(), 'JavaScript from pipe');
+  assert.strictEqual(stderr, '');
+}));