diff --git a/pandas/tests/series/methods/test_isin.py b/pandas/tests/series/methods/test_isin.py
index 92ebee9ffa7a5..3e4857b7abf38 100644
--- a/pandas/tests/series/methods/test_isin.py
+++ b/pandas/tests/series/methods/test_isin.py
@@ -234,3 +234,15 @@ def test_isin_filtering_with_mixed_object_types(data, is_in):
     expected = Series([True, False])
 
     tm.assert_series_equal(result, expected)
+
+
+@pytest.mark.parametrize("data", [[1, 2, 3], [1.0, 2.0, 3.0]])
+@pytest.mark.parametrize("isin", [[1, 2], [1.0, 2.0]])
+def test_isin_filtering_on_iterable(data, isin):
+    # GH 50234
+
+    ser = Series(data)
+    result = ser.isin(i for i in isin)
+    expected_result = Series([True, True, False])
+
+    tm.assert_series_equal(result, expected_result)