diff --git a/python/release/wheel/Dockerfile-AArch64 b/python/release/wheel/Dockerfile-AArch64
new file mode 100644
index 0000000000000..5744e793b52a1
--- /dev/null
+++ b/python/release/wheel/Dockerfile-AArch64
@@ -0,0 +1,6 @@
+FROM quay.io/pypa/manylinux2014_aarch64
+
+RUN yum install -y libtool gcc-c++ gcc
+RUN /opt/python/cp36-cp36m/bin/pip install twine
+
+COPY protobuf_optimized_pip.sh /
diff --git a/python/release/wheel/Dockerfile b/python/release/wheel/Dockerfile-x86_64
similarity index 66%
rename from python/release/wheel/Dockerfile
rename to python/release/wheel/Dockerfile-x86_64
index f38ec2f5847a6..af4085951daee 100644
--- a/python/release/wheel/Dockerfile
+++ b/python/release/wheel/Dockerfile-x86_64
@@ -1,6 +1,6 @@
 FROM quay.io/pypa/manylinux1_x86_64
 
 RUN yum install -y libtool
-RUN /opt/python/cp27-cp27mu/bin/pip install twine
+RUN /opt/python/cp36-cp36m/bin/pip install twine
 
 COPY protobuf_optimized_pip.sh /
diff --git a/python/release/wheel/build_wheel_manylinux.sh b/python/release/wheel/build_wheel_manylinux.sh
index 39fd8c1273884..ae1cd65e312a2 100755
--- a/python/release/wheel/build_wheel_manylinux.sh
+++ b/python/release/wheel/build_wheel_manylinux.sh
@@ -20,8 +20,12 @@ fi
 PROTOBUF_VERSION=$1
 PYPI_USERNAME=$2
 PYPI_PASSWORD=$3
+PLAT=x86_64
+if [ `uname -m` = 'aarch64' ]; then
+  PLAT=AArch64
+fi
 
 docker rmi protobuf-python-wheel
-docker build . -t protobuf-python-wheel
+docker build . -f Dockerfile-${PLAT} -t protobuf-python-wheel
 docker run --rm protobuf-python-wheel ./protobuf_optimized_pip.sh $PROTOBUF_VERSION $PYPI_USERNAME $PYPI_PASSWORD
 docker rmi protobuf-python-wheel
diff --git a/python/release/wheel/protobuf_optimized_pip.sh b/python/release/wheel/protobuf_optimized_pip.sh
index 07c2a093bba7c..5dc822e2df956 100755
--- a/python/release/wheel/protobuf_optimized_pip.sh
+++ b/python/release/wheel/protobuf_optimized_pip.sh
@@ -15,8 +15,13 @@ function build_wheel() {
   PYTHON_VERSION=$1
   PYTHON_BIN=/opt/python/${PYTHON_VERSION}/bin/python
 
+  PLAT=x86_64
+  if [ `uname -m` = 'aarch64' ]; then
+    PLAT=aarch64
+  fi
+
   $PYTHON_BIN setup.py bdist_wheel --cpp_implementation --compile_static_extension
-  auditwheel repair dist/protobuf-${PROTOBUF_VERSION}-${PYTHON_VERSION}-linux_x86_64.whl
+  auditwheel repair dist/protobuf-${PROTOBUF_VERSION}-${PYTHON_VERSION}-linux_${PLAT}.whl
 }
 
 # Validate arguments.
@@ -36,6 +41,9 @@ PYPI_PASSWORD=$3
 
 DIR=${PWD}/'protobuf-python-build'
 PYTHON_VERSIONS=('cp27-cp27mu' 'cp33-cp33m' 'cp34-cp34m' 'cp35-cp35m' 'cp36-cp36m')
+if [ `uname -m` = 'aarch64' ]; then
+  PYTHON_VERSIONS=('cp36-cp36m' 'cp37-cp37m' 'cp38-cp38')
+fi
 
 mkdir -p ${DIR}
 cd ${DIR}
@@ -63,4 +71,4 @@ do
   build_wheel $PYTHON_VERSION
 done
 
-/opt/python/cp27-cp27mu/bin/twine upload wheelhouse/*
+/opt/python/cp36-cp36m/bin/twine upload wheelhouse/*