diff --git a/changelog/5278.bugfix.rst b/changelog/5278.bugfix.rst
new file mode 100644
index 00000000000..88b211ba837
--- /dev/null
+++ b/changelog/5278.bugfix.rst
@@ -0,0 +1 @@
+Pytest's internal python plugin can be disabled using ``-p python`` now again.
diff --git a/src/_pytest/assertion/rewrite.py b/src/_pytest/assertion/rewrite.py
index 2903b89957e..9f87f55391c 100644
--- a/src/_pytest/assertion/rewrite.py
+++ b/src/_pytest/assertion/rewrite.py
@@ -60,7 +60,10 @@ class AssertionRewritingHook(object):
 
     def __init__(self, config):
         self.config = config
-        self.fnpats = config.getini("python_files")
+        try:
+            self.fnpats = config.getini("python_files")
+        except ValueError:
+            self.fnpats = ["test_*.py", "*_test.py"]
         self.session = None
         self.modules = {}
         self._rewritten_names = set()
diff --git a/src/_pytest/config/__init__.py b/src/_pytest/config/__init__.py
index 03769b8153f..e630b199c76 100644
--- a/src/_pytest/config/__init__.py
+++ b/src/_pytest/config/__init__.py
@@ -113,16 +113,16 @@ def directory_arg(path, optname):
 
 
 # Plugins that cannot be disabled via "-p no:X" currently.
-essential_plugins = (
+essential_plugins = (  # fmt: off
     "mark",
     "main",
     "runner",
-    "python",
     "fixtures",
     "helpconfig",  # Provides -p.
-)
+)  # fmt: on
 
 default_plugins = essential_plugins + (
+    "python",
     "terminal",
     "debugging",
     "unittest",
diff --git a/src/_pytest/fixtures.py b/src/_pytest/fixtures.py
index 90290445717..0a6e04600eb 100644
--- a/src/_pytest/fixtures.py
+++ b/src/_pytest/fixtures.py
@@ -1075,6 +1075,15 @@ def test_foo(pytestconfig):
     return request.config
 
 
+def pytest_addoption(parser):
+    parser.addini(
+        "usefixtures",
+        type="args",
+        default=[],
+        help="list of default fixtures to be used with this project",
+    )
+
+
 class FixtureManager(object):
     """
     pytest fixtures definitions and information is stored and managed
diff --git a/src/_pytest/python.py b/src/_pytest/python.py
index 18d90985536..a6edff0af57 100644
--- a/src/_pytest/python.py
+++ b/src/_pytest/python.py
@@ -79,15 +79,10 @@ def pytest_addoption(parser):
         default=False,
         help="show fixtures per test",
     )
-    parser.addini(
-        "usefixtures",
-        type="args",
-        default=[],
-        help="list of default fixtures to be used with this project",
-    )
     parser.addini(
         "python_files",
         type="args",
+        # NOTE: default is also used in AssertionRewritingHook.
         default=["test_*.py", "*_test.py"],
         help="glob-style file patterns for Python test module discovery",
     )
diff --git a/testing/test_config.py b/testing/test_config.py
index ecb8fd4036e..cee3c64039d 100644
--- a/testing/test_config.py
+++ b/testing/test_config.py
@@ -1228,6 +1228,17 @@ def test_config_blocked_default_plugins(testdir, plugin):
 
     p = testdir.makepyfile("def test(): pass")
     result = testdir.runpytest(str(p), "-pno:%s" % plugin)
+
+    if plugin == "python":
+        assert result.ret == EXIT_USAGEERROR
+        result.stderr.fnmatch_lines(
+            [
+                "ERROR: not found: */test_config_blocked_default_plugins.py",
+                "(no name '*/test_config_blocked_default_plugins.py' in any of [])",
+            ]
+        )
+        return
+
     assert result.ret == EXIT_OK
     if plugin != "terminal":
         result.stdout.fnmatch_lines(["* 1 passed in *"])