diff --git a/.github/workflows/main.yml b/.github/workflows/main.yml
index ccdf4055..a8f29435 100644
--- a/.github/workflows/main.yml
+++ b/.github/workflows/main.yml
@@ -17,7 +17,7 @@ jobs:
 
     strategy:
       matrix:
-        python-version: ["3.7", "3.8", "3.9", "3.10.0-rc.1"] 
+        python-version: ["3.7", "3.8", "3.9", "3.10.0"] 
 
     steps:
       - uses: "actions/checkout@v2"
@@ -57,7 +57,7 @@ jobs:
           python-version: "3.9"
 
       - name: "Install poetry, check-wheel-content, and twine"
-        run: "python -m pip install poetry twine check-wheel-contents"
+        run: "python -m pip install poetry==1.2.0a2 twine check-wheel-contents"
       - name: "Build package"
         run: "poetry build"
       - name: "List result"
diff --git a/poetry.lock b/poetry.lock
index 6087c21c..d4d4b0bb 100644
--- a/poetry.lock
+++ b/poetry.lock
@@ -41,7 +41,7 @@ pytz = ">=2015.7"
 
 [[package]]
 name = "backports.entry-points-selectable"
-version = "1.1.0"
+version = "1.1.1"
 description = "Compatibility shim providing selectable entry points for older implementations"
 category = "dev"
 optional = false
@@ -52,18 +52,18 @@ importlib-metadata = {version = "*", markers = "python_version < \"3.8\""}
 
 [package.extras]
 docs = ["sphinx", "jaraco.packaging (>=8.2)", "rst.linker (>=1.9)"]
-testing = ["pytest (>=4.6)", "pytest-flake8", "pytest-cov", "pytest-black (>=0.3.7)", "pytest-mypy", "pytest-checkdocs (>=2.4)", "pytest-enabler (>=1.0.1)"]
+testing = ["pytest", "pytest-flake8", "pytest-cov", "pytest-black (>=0.3.7)", "pytest-mypy", "pytest-checkdocs (>=2.4)", "pytest-enabler (>=1.0.1)"]
 
 [[package]]
 name = "beautifulsoup4"
-version = "4.9.3"
+version = "4.10.0"
 description = "Screen-scraping library"
 category = "dev"
 optional = false
-python-versions = "*"
+python-versions = ">3.0.0"
 
 [package.dependencies]
-soupsieve = {version = ">1.2", markers = "python_version >= \"3.0\""}
+soupsieve = ">1.2"
 
 [package.extras]
 html5lib = ["html5lib"]
@@ -71,7 +71,7 @@ lxml = ["lxml"]
 
 [[package]]
 name = "black"
-version = "21.8b0"
+version = "21.11b0"
 description = "The uncompromising code formatter."
 category = "dev"
 optional = false
@@ -84,7 +84,7 @@ pathspec = ">=0.9.0,<1"
 platformdirs = ">=2"
 regex = ">=2020.1.8"
 tomli = ">=0.2.6,<2.0.0"
-typed-ast = {version = ">=1.4.2", markers = "python_version < \"3.8\""}
+typed-ast = {version = ">=1.4.2", markers = "python_version < \"3.8\" and implementation_name == \"cpython\""}
 typing-extensions = [
     {version = ">=3.10.0.0", markers = "python_version < \"3.10\""},
     {version = "!=3.10.0.1", markers = "python_version >= \"3.10\""},
@@ -92,14 +92,14 @@ typing-extensions = [
 
 [package.extras]
 colorama = ["colorama (>=0.4.3)"]
-d = ["aiohttp (>=3.6.0)", "aiohttp-cors (>=0.4.0)"]
+d = ["aiohttp (>=3.7.4)"]
 jupyter = ["ipython (>=7.8.0)", "tokenize-rt (>=3.2.0)"]
-python2 = ["typed-ast (>=1.4.2)"]
+python2 = ["typed-ast (>=1.4.3)"]
 uvloop = ["uvloop (>=0.15.2)"]
 
 [[package]]
 name = "certifi"
-version = "2021.5.30"
+version = "2021.10.8"
 description = "Python package for providing Mozilla's CA Bundle."
 category = "dev"
 optional = false
@@ -107,7 +107,7 @@ python-versions = "*"
 
 [[package]]
 name = "charset-normalizer"
-version = "2.0.4"
+version = "2.0.7"
 description = "The Real First Universal Charset Detector. Open, modern and actively maintained alternative to Chardet."
 category = "dev"
 optional = false
@@ -118,7 +118,7 @@ unicode_backport = ["unicodedata2"]
 
 [[package]]
 name = "click"
-version = "8.0.1"
+version = "8.0.3"
 description = "Composable command line interface toolkit"
 category = "dev"
 optional = false
@@ -149,7 +149,7 @@ toml = ["toml"]
 
 [[package]]
 name = "distlib"
-version = "0.3.2"
+version = "0.3.3"
 description = "Distribution utilities"
 category = "dev"
 optional = false
@@ -165,11 +165,15 @@ python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*, !=3.4.*"
 
 [[package]]
 name = "filelock"
-version = "3.0.12"
+version = "3.4.0"
 description = "A platform independent file lock."
 category = "dev"
 optional = false
-python-versions = "*"
+python-versions = ">=3.6"
+
+[package.extras]
+docs = ["furo (>=2021.8.17b43)", "sphinx (>=4.1)", "sphinx-autodoc-typehints (>=1.12)"]
+testing = ["covdefaults (>=1.2.0)", "coverage (>=4)", "pytest (>=4)", "pytest-cov", "pytest-timeout (>=1.4.2)"]
 
 [[package]]
 name = "flake8"
@@ -187,7 +191,7 @@ pyflakes = ">=2.3.0,<2.4.0"
 
 [[package]]
 name = "furo"
-version = "2021.8.31"
+version = "2021.11.16"
 description = "A clean customisable Sphinx documentation theme."
 category = "dev"
 optional = false
@@ -198,12 +202,12 @@ beautifulsoup4 = "*"
 sphinx = ">=4.0,<5.0"
 
 [package.extras]
-doc = ["myst-parser", "sphinx-copybutton", "sphinx-design", "sphinx-inline-tabs"]
 test = ["pytest", "pytest-cov", "pytest-xdist"]
+doc = ["myst-parser", "sphinx-copybutton", "sphinx-design", "sphinx-inline-tabs"]
 
 [[package]]
 name = "hypothesis"
-version = "6.17.4"
+version = "6.24.5"
 description = "A library for property-based testing"
 category = "dev"
 optional = false
@@ -231,7 +235,7 @@ zoneinfo = ["importlib-resources (>=3.3.0)", "backports.zoneinfo (>=0.2.1)", "tz
 
 [[package]]
 name = "idna"
-version = "3.2"
+version = "3.3"
 description = "Internationalized Domain Names in Applications (IDNA)"
 category = "dev"
 optional = false
@@ -239,7 +243,7 @@ python-versions = ">=3.5"
 
 [[package]]
 name = "imagesize"
-version = "1.2.0"
+version = "1.3.0"
 description = "Getting image size from png/jpeg/jpeg2000/gif file"
 category = "dev"
 optional = false
@@ -258,7 +262,7 @@ test = ["flake8 (>=3.8.4,<3.9.0)", "pycodestyle (>=2.6.0,<2.7.0)"]
 
 [[package]]
 name = "importlib-metadata"
-version = "4.8.1"
+version = "4.8.2"
 description = "Read metadata from Python packages"
 category = "dev"
 optional = false
@@ -271,7 +275,7 @@ zipp = ">=0.5"
 [package.extras]
 docs = ["sphinx", "jaraco.packaging (>=8.2)", "rst.linker (>=1.9)"]
 perf = ["ipython"]
-testing = ["pytest (>=4.6)", "pytest-checkdocs (>=2.4)", "pytest-flake8", "pytest-cov", "pytest-enabler (>=1.0.1)", "packaging", "pep517", "pyfakefs", "flufl.flake8", "pytest-perf (>=0.9.2)", "pytest-black (>=0.3.7)", "pytest-mypy", "importlib-resources (>=1.3)"]
+testing = ["pytest (>=6)", "pytest-checkdocs (>=2.4)", "pytest-flake8", "pytest-cov", "pytest-enabler (>=1.0.1)", "packaging", "pep517", "pyfakefs", "flufl.flake8", "pytest-perf (>=0.9.2)", "pytest-black (>=0.3.7)", "pytest-mypy", "importlib-resources (>=1.3)"]
 
 [[package]]
 name = "iniconfig"
@@ -283,7 +287,7 @@ python-versions = "*"
 
 [[package]]
 name = "isort"
-version = "5.9.3"
+version = "5.10.1"
 description = "A Python utility / library to sort Python imports."
 category = "dev"
 optional = false
@@ -297,7 +301,7 @@ plugins = ["setuptools"]
 
 [[package]]
 name = "jinja2"
-version = "3.0.1"
+version = "3.0.3"
 description = "A very fast and expressive template engine."
 category = "dev"
 optional = false
@@ -325,20 +329,6 @@ category = "dev"
 optional = false
 python-versions = "*"
 
-[[package]]
-name = "motor"
-version = "2.5.1"
-description = "Non-blocking MongoDB driver for Tornado or asyncio"
-category = "dev"
-optional = false
-python-versions = ">=3.5.2"
-
-[package.dependencies]
-pymongo = ">=3.12,<4"
-
-[package.extras]
-encryption = ["pymongo[encryption] (>=3.12,<4)"]
-
 [[package]]
 name = "msgpack"
 version = "1.0.2"
@@ -357,7 +347,7 @@ python-versions = "*"
 
 [[package]]
 name = "orjson"
-version = "3.6.3"
+version = "3.6.4"
 description = "Fast, correct Python JSON library supporting dataclasses, datetimes, and numpy"
 category = "dev"
 optional = false
@@ -365,14 +355,14 @@ python-versions = ">=3.7"
 
 [[package]]
 name = "packaging"
-version = "21.0"
+version = "21.3"
 description = "Core utilities for Python packages"
 category = "dev"
 optional = false
 python-versions = ">=3.6"
 
 [package.dependencies]
-pyparsing = ">=2.0.2"
+pyparsing = ">=2.0.2,<3.0.5 || >3.0.5"
 
 [[package]]
 name = "pathspec"
@@ -396,7 +386,7 @@ pytzdata = ">=2020.1"
 
 [[package]]
 name = "platformdirs"
-version = "2.3.0"
+version = "2.4.0"
 description = "A small Python module for determining appropriate platform-specific dirs, e.g. a \"user data dir\"."
 category = "dev"
 optional = false
@@ -423,11 +413,11 @@ testing = ["pytest", "pytest-benchmark"]
 
 [[package]]
 name = "py"
-version = "1.10.0"
+version = "1.11.0"
 description = "library with cross-python path, ini-parsing, io, code, log facilities"
 category = "dev"
 optional = false
-python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*"
+python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*, !=3.4.*"
 
 [[package]]
 name = "py-cpuinfo"
@@ -463,7 +453,7 @@ python-versions = ">=3.5"
 
 [[package]]
 name = "pymongo"
-version = "3.12.0"
+version = "3.12.1"
 description = "Python driver for MongoDB <http://www.mongodb.org>"
 category = "dev"
 optional = false
@@ -481,11 +471,14 @@ zstd = ["zstandard"]
 
 [[package]]
 name = "pyparsing"
-version = "2.4.7"
+version = "3.0.6"
 description = "Python parsing module"
 category = "dev"
 optional = false
-python-versions = ">=2.6, !=3.0.*, !=3.1.*, !=3.2.*"
+python-versions = ">=3.6"
+
+[package.extras]
+diagrams = ["jinja2", "railroad-diagrams"]
 
 [[package]]
 name = "pytest"
@@ -539,7 +532,7 @@ six = ">=1.5"
 
 [[package]]
 name = "pytz"
-version = "2021.1"
+version = "2021.3"
 description = "World timezone definitions, modern and historical"
 category = "dev"
 optional = false
@@ -563,7 +556,7 @@ python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*, !=3.4.*, !=3.5.*"
 
 [[package]]
 name = "regex"
-version = "2021.8.28"
+version = "2021.11.10"
 description = "Alternative regular expression module, to replace re."
 category = "dev"
 optional = false
@@ -589,7 +582,7 @@ use_chardet_on_py3 = ["chardet (>=3.0.2,<5)"]
 
 [[package]]
 name = "setuptools"
-version = "57.4.0"
+version = "59.1.1"
 description = "Easily download, build, install, upgrade, and uninstall Python packages"
 category = "dev"
 optional = false
@@ -597,7 +590,7 @@ python-versions = ">=3.6"
 
 [package.extras]
 docs = ["sphinx", "jaraco.packaging (>=8.2)", "rst.linker (>=1.9)", "jaraco.tidelift (>=1.4)", "pygments-github-lexers (==0.0.5)", "sphinx-inline-tabs", "sphinxcontrib-towncrier", "furo"]
-testing = ["pytest (>=4.6)", "pytest-checkdocs (>=2.4)", "pytest-flake8", "pytest-cov", "pytest-enabler (>=1.0.1)", "mock", "flake8-2020", "virtualenv (>=13.0.0)", "pytest-virtualenv (>=1.2.7)", "wheel", "paver", "pip (>=19.1)", "jaraco.envs", "pytest-xdist", "sphinx", "jaraco.path (>=3.2.0)", "pytest-black (>=0.3.7)", "pytest-mypy"]
+testing = ["pytest (>=6)", "pytest-checkdocs (>=2.4)", "pytest-flake8", "pytest-cov", "pytest-enabler (>=1.0.1)", "mock", "flake8-2020", "virtualenv (>=13.0.0)", "pytest-virtualenv (>=1.2.7)", "wheel", "paver", "pip (>=19.1)", "jaraco.envs (>=2.2)", "pytest-xdist", "sphinx", "jaraco.path (>=3.2.0)", "pytest-black (>=0.3.7)", "pytest-mypy"]
 
 [[package]]
 name = "six"
@@ -609,7 +602,7 @@ python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*"
 
 [[package]]
 name = "snowballstemmer"
-version = "2.1.0"
+version = "2.2.0"
 description = "This package provides 29 stemmers for 28 languages generated from Snowball algorithms."
 category = "dev"
 optional = false
@@ -625,7 +618,7 @@ python-versions = "*"
 
 [[package]]
 name = "soupsieve"
-version = "2.2.1"
+version = "2.3.1"
 description = "A modern CSS selector implementation for Beautiful Soup."
 category = "dev"
 optional = false
@@ -633,7 +626,7 @@ python-versions = ">=3.6"
 
 [[package]]
 name = "sphinx"
-version = "4.1.2"
+version = "4.3.0"
 description = "Python documentation generator"
 category = "dev"
 optional = false
@@ -744,7 +737,7 @@ python-versions = ">=2.6, !=3.0.*, !=3.1.*, !=3.2.*"
 
 [[package]]
 name = "tomli"
-version = "1.2.1"
+version = "1.2.2"
 description = "A lil' TOML parser"
 category = "dev"
 optional = false
@@ -760,7 +753,7 @@ python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*, !=3.4.*"
 
 [[package]]
 name = "tox"
-version = "3.24.3"
+version = "3.24.4"
 description = "tox is a generic virtualenv management and test command line tool"
 category = "dev"
 optional = false
@@ -783,23 +776,23 @@ testing = ["flaky (>=3.4.0)", "freezegun (>=0.3.11)", "psutil (>=5.6.1)", "pytes
 
 [[package]]
 name = "typed-ast"
-version = "1.4.3"
+version = "1.5.0"
 description = "a fork of Python 2 and 3 ast modules with type comment support"
 category = "dev"
 optional = false
-python-versions = "*"
+python-versions = ">=3.6"
 
 [[package]]
 name = "typing-extensions"
-version = "3.10.0.2"
-description = "Backported and Experimental Type Hints for Python 3.5+"
-category = "dev"
+version = "4.0.0"
+description = "Backported and Experimental Type Hints for Python 3.6+"
+category = "main"
 optional = false
-python-versions = "*"
+python-versions = ">=3.6"
 
 [[package]]
 name = "ujson"
-version = "4.1.0"
+version = "4.2.0"
 description = "Ultra fast JSON encoder and decoder for Python"
 category = "dev"
 optional = false
@@ -807,7 +800,7 @@ python-versions = ">=3.6"
 
 [[package]]
 name = "urllib3"
-version = "1.26.6"
+version = "1.26.7"
 description = "HTTP library with thread-safe connection pooling, file post, and more."
 category = "dev"
 optional = false
@@ -820,7 +813,7 @@ socks = ["PySocks (>=1.5.6,!=1.5.7,<2.0)"]
 
 [[package]]
 name = "virtualenv"
-version = "20.7.2"
+version = "20.10.0"
 description = "Virtual Python Environment builder"
 category = "dev"
 optional = false
@@ -829,18 +822,18 @@ python-versions = "!=3.0.*,!=3.1.*,!=3.2.*,!=3.3.*,!=3.4.*,>=2.7"
 [package.dependencies]
 "backports.entry-points-selectable" = ">=1.0.4"
 distlib = ">=0.3.1,<1"
-filelock = ">=3.0.0,<4"
+filelock = ">=3.2,<4"
 importlib-metadata = {version = ">=0.12", markers = "python_version < \"3.8\""}
 platformdirs = ">=2,<3"
 six = ">=1.9.0,<2"
 
 [package.extras]
-docs = ["proselint (>=0.10.2)", "sphinx (>=3)", "sphinx-argparse (>=0.2.5)", "sphinx-rtd-theme (>=0.4.3)", "towncrier (>=19.9.0rc1)"]
+docs = ["proselint (>=0.10.2)", "sphinx (>=3)", "sphinx-argparse (>=0.2.5)", "sphinx-rtd-theme (>=0.4.3)", "towncrier (>=21.3)"]
 testing = ["coverage (>=4)", "coverage-enable-subprocess (>=1)", "flaky (>=3)", "pytest (>=4)", "pytest-env (>=0.6.2)", "pytest-freezegun (>=0.4.1)", "pytest-mock (>=2)", "pytest-randomly (>=1)", "pytest-timeout (>=1)", "packaging (>=20.0)"]
 
 [[package]]
 name = "zipp"
-version = "3.5.0"
+version = "3.6.0"
 description = "Backport of pathlib-compatible object wrapper for zip files"
 category = "dev"
 optional = false
@@ -853,7 +846,7 @@ testing = ["pytest (>=4.6)", "pytest-checkdocs (>=2.4)", "pytest-flake8", "pytes
 [metadata]
 lock-version = "1.1"
 python-versions = "^3.7"
-content-hash = "a2cfae67bfc15ba3c32e6393463ba579b0c0e25acf267223bec5a19af4b94afd"
+content-hash = "f1898717d22e99324064aa935895b18b85d7be1d2bbd4d574960055be2e5b628"
 
 [metadata.files]
 alabaster = [
@@ -873,29 +866,28 @@ babel = [
     {file = "Babel-2.9.1.tar.gz", hash = "sha256:bc0c176f9f6a994582230df350aa6e05ba2ebe4b3ac317eab29d9be5d2768da0"},
 ]
 "backports.entry-points-selectable" = [
-    {file = "backports.entry_points_selectable-1.1.0-py2.py3-none-any.whl", hash = "sha256:a6d9a871cde5e15b4c4a53e3d43ba890cc6861ec1332c9c2428c92f977192acc"},
-    {file = "backports.entry_points_selectable-1.1.0.tar.gz", hash = "sha256:988468260ec1c196dab6ae1149260e2f5472c9110334e5d51adcb77867361f6a"},
+    {file = "backports.entry_points_selectable-1.1.1-py2.py3-none-any.whl", hash = "sha256:7fceed9532a7aa2bd888654a7314f864a3c16a4e710b34a58cfc0f08114c663b"},
+    {file = "backports.entry_points_selectable-1.1.1.tar.gz", hash = "sha256:914b21a479fde881635f7af5adc7f6e38d6b274be32269070c53b698c60d5386"},
 ]
 beautifulsoup4 = [
-    {file = "beautifulsoup4-4.9.3-py2-none-any.whl", hash = "sha256:4c98143716ef1cb40bf7f39a8e3eec8f8b009509e74904ba3a7b315431577e35"},
-    {file = "beautifulsoup4-4.9.3-py3-none-any.whl", hash = "sha256:fff47e031e34ec82bf17e00da8f592fe7de69aeea38be00523c04623c04fb666"},
-    {file = "beautifulsoup4-4.9.3.tar.gz", hash = "sha256:84729e322ad1d5b4d25f805bfa05b902dd96450f43842c4e99067d5e1369eb25"},
+    {file = "beautifulsoup4-4.10.0-py3-none-any.whl", hash = "sha256:9a315ce70049920ea4572a4055bc4bd700c940521d36fc858205ad4fcde149bf"},
+    {file = "beautifulsoup4-4.10.0.tar.gz", hash = "sha256:c23ad23c521d818955a4151a67d81580319d4bf548d3d49f4223ae041ff98891"},
 ]
 black = [
-    {file = "black-21.8b0-py3-none-any.whl", hash = "sha256:2a0f9a8c2b2a60dbcf1ccb058842fb22bdbbcb2f32c6cc02d9578f90b92ce8b7"},
-    {file = "black-21.8b0.tar.gz", hash = "sha256:570608d28aa3af1792b98c4a337dbac6367877b47b12b88ab42095cfc1a627c2"},
+    {file = "black-21.11b0-py3-none-any.whl", hash = "sha256:0b1f66cbfadcd332ceeaeecf6373d9991d451868d2e2219ad0ac1213fb701117"},
+    {file = "black-21.11b0.tar.gz", hash = "sha256:83f3852301c8dcb229e9c444dd79f573c8d31c7c2dad9bbaaa94c808630e32aa"},
 ]
 certifi = [
-    {file = "certifi-2021.5.30-py2.py3-none-any.whl", hash = "sha256:50b1e4f8446b06f41be7dd6338db18e0990601dce795c2b1686458aa7e8fa7d8"},
-    {file = "certifi-2021.5.30.tar.gz", hash = "sha256:2bbf76fd432960138b3ef6dda3dde0544f27cbf8546c458e60baf371917ba9ee"},
+    {file = "certifi-2021.10.8-py2.py3-none-any.whl", hash = "sha256:d62a0163eb4c2344ac042ab2bdf75399a71a2d8c7d47eac2e2ee91b9d6339569"},
+    {file = "certifi-2021.10.8.tar.gz", hash = "sha256:78884e7c1d4b00ce3cea67b44566851c4343c120abd683433ce934a68ea58872"},
 ]
 charset-normalizer = [
-    {file = "charset-normalizer-2.0.4.tar.gz", hash = "sha256:f23667ebe1084be45f6ae0538e4a5a865206544097e4e8bbcacf42cd02a348f3"},
-    {file = "charset_normalizer-2.0.4-py3-none-any.whl", hash = "sha256:0c8911edd15d19223366a194a513099a302055a962bca2cec0f54b8b63175d8b"},
+    {file = "charset-normalizer-2.0.7.tar.gz", hash = "sha256:e019de665e2bcf9c2b64e2e5aa025fa991da8720daa3c1138cadd2fd1856aed0"},
+    {file = "charset_normalizer-2.0.7-py3-none-any.whl", hash = "sha256:f7af805c321bfa1ce6714c51f254e0d5bb5e5834039bc17db7ebe3a4cec9492b"},
 ]
 click = [
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 ]
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diff --git a/pyproject.toml b/pyproject.toml
index 7d34d7bc..c8859dab 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -24,8 +24,10 @@ readme = "README.rst"
 [tool.poetry.dependencies]
 python = "^3.7"
 attrs = ">= 20"
+typing_extensions = { version = "*", python = "~3.7" }
 
-[tool.poetry.dev-dependencies]
+[tool.poetry.group.dev.dependencies]
+pymongo = "^3.12.1"
 flake8 = "^3.9.0"
 tox = "^3.23.0"
 coverage = "^5.5"
@@ -42,7 +44,6 @@ orjson = "^3.5.2"
 msgpack = "^1.0.2"
 PyYAML = "^5.4.1"
 tomlkit = "^0.7.0"
-motor = "^2.5.0"
 furo = "^2021.7.31-beta.41"
 
 [tool.poetry.urls]
diff --git a/src/cattr/_compat.py b/src/cattr/_compat.py
index 4ad9935b..1eec4827 100644
--- a/src/cattr/_compat.py
+++ b/src/cattr/_compat.py
@@ -29,9 +29,10 @@ def get_args(cl):
     def get_origin(cl):
         return getattr(cl, "__origin__", None)
 
+    from typing_extensions import Protocol
 
 else:
-    from typing import get_args, get_origin  # NOQA
+    from typing import Protocol, get_args, get_origin  # NOQA
 
 
 def has(cls):
@@ -92,6 +93,10 @@ def is_hetero_tuple(type: Any) -> bool:
     return origin is tuple and ... not in type.__args__
 
 
+def is_protocol(type: Any) -> bool:
+    return issubclass(type, Protocol) and getattr(type, "_is_protocol", False)
+
+
 if is_py37 or is_py38:
     Set = TypingSet
     MutableSet = TypingMutableSet
@@ -202,6 +207,7 @@ def copy_with(type, args):
     from collections.abc import Sequence as AbcSequence
     from collections.abc import Set as AbcSet
     from types import GenericAlias
+    from typing import Annotated
     from typing import Counter as TypingCounter
     from typing import (
         Union,
@@ -353,6 +359,9 @@ def is_generic(obj):
 
     def copy_with(type, args):
         """Replace a generic type's arguments."""
+        if is_annotated(type):
+            # typing.Annotated requires a special case.
+            return Annotated[args]  # type: ignore
         return type.__origin__[args]
 
 
diff --git a/src/cattr/converters.py b/src/cattr/converters.py
index edb62a9e..e5620224 100644
--- a/src/cattr/converters.py
+++ b/src/cattr/converters.py
@@ -31,6 +31,7 @@
     is_literal,
     is_mapping,
     is_mutable_set,
+    is_protocol,
     is_sequence,
     is_tuple,
     is_union_type,
@@ -129,6 +130,10 @@ def __init__(
         )
         self._unstructure_func.register_func_list(
             [
+                (
+                    is_protocol,
+                    lambda v: self.unstructure(v, unstructure_as=v.__class__),
+                ),
                 (is_mapping, self._unstructure_mapping),
                 (is_sequence, self._unstructure_seq),
                 (is_mutable_set, self._unstructure_seq),
@@ -704,9 +709,7 @@ def gen_structure_annotated(self, type):
 
     def gen_unstructure_attrs_fromdict(self, cl: Type[T]) -> Dict[str, Any]:
         origin = get_origin(cl)
-        if origin is not None:
-            cl = origin
-        attribs = fields(cl)
+        attribs = fields(origin or cl)
         if any(isinstance(a.type, str) for a in attribs):
             # PEP 563 annotations - need to be resolved.
             resolve_types(cl)
diff --git a/src/cattr/gen.py b/src/cattr/gen.py
index 589e42c7..9d72ce9b 100644
--- a/src/cattr/gen.py
+++ b/src/cattr/gen.py
@@ -10,13 +10,13 @@
 
 from ._compat import (
     adapted_fields,
-    copy_with,
     get_args,
     get_origin,
     is_annotated,
     is_bare,
     is_generic,
 )
+from .generics import deep_copy_with
 
 if TYPE_CHECKING:  # pragma: no cover
     from cattr.converters import Converter
@@ -47,14 +47,29 @@ def make_dict_unstructure_fn(
     **kwargs,
 ):
     """Generate a specialized dict unstructuring function for an attrs class."""
+    origin = get_origin(cl)
+    attrs = adapted_fields(origin or cl)  # type: ignore
+
+    if any(isinstance(a.type, str) for a in attrs):
+        # PEP 563 annotations - need to be resolved.
+        resolve_types(cl)
+
+    mapping = {}
+    if is_generic(cl):
+        mapping = _generate_mapping(cl, mapping)
+
+        for base in getattr(origin, "__orig_bases__", ()):
+            if is_generic(base) and not str(base).startswith("typing.Generic"):
+                mapping = _generate_mapping(base, mapping)
+                break
+        cl = origin
+
     cl_name = cl.__name__
     fn_name = "unstructure_" + cl_name
     globs = {}
     lines = []
     post_lines = []
 
-    attrs = adapted_fields(cl)  # type: ignore
-
     # We keep track of what we're generating to help with recursive
     # class graphs.
     try:
@@ -66,6 +81,7 @@ def make_dict_unstructure_fn(
         raise RecursionError()
     else:
         working_set.add(cl)
+
     try:
         lines.append(f"def {fn_name}(instance):")
         lines.append("    res = {")
@@ -80,12 +96,23 @@ def make_dict_unstructure_fn(
             # For each attribute, we try resolving the type here and now.
             # If a type is manually overwritten, this function should be
             # regenerated.
+            handler = None
             if a.type is not None:
-                try:
-                    handler = converter._unstructure_func.dispatch(a.type)
-                except RecursionError:
-                    # There's a circular reference somewhere down the line
-                    handler = converter.unstructure
+                t = a.type
+                if isinstance(t, TypeVar):
+                    if t.__name__ in mapping:
+                        t = mapping[t.__name__]
+                    else:
+                        handler = converter.unstructure
+                elif is_generic(t) and not is_bare(t) and not is_annotated(t):
+                    t = deep_copy_with(t, mapping)
+
+                if handler is None:
+                    try:
+                        handler = converter._unstructure_func.dispatch(t)
+                    except RecursionError:
+                        # There's a circular reference somewhere down the line
+                        handler = converter.unstructure
             else:
                 handler = converter.unstructure
 
@@ -217,14 +244,7 @@ def make_dict_structure_fn(
         if isinstance(t, TypeVar):
             t = mapping.get(t.__name__, t)
         elif is_generic(t) and not is_bare(t) and not is_annotated(t):
-            concrete_types = tuple(
-                mapping.get(t.__name__, t)
-                if isinstance(t, TypeVar)
-                or (getattr(t, "__name__", None) and is_generic(t))
-                else t
-                for t in get_args(t)
-            )
-            t = copy_with(t, concrete_types)
+            t = deep_copy_with(t, mapping)
 
         # For each attribute, we try resolving the type here and now.
         # If a type is manually overwritten, this function should be
@@ -300,8 +320,10 @@ def make_iterable_unstructure_fn(cl: Any, converter, unstructure_to=None):
     # Let's try fishing out the type args.
     if getattr(cl, "__args__", None) is not None:
         type_arg = get_args(cl)[0]
-        # We can do the dispatch here and now.
-        handler = converter._unstructure_func.dispatch(type_arg)
+        # We don't know how to handle the TypeVar on this level,
+        # so we skip doing the dispatch here.
+        if not isinstance(type_arg, TypeVar):
+            handler = converter._unstructure_func.dispatch(type_arg)
 
     globs = {"__cattr_seq_cl": unstructure_to or cl, "__cattr_u": handler}
     lines = []
diff --git a/src/cattr/generics.py b/src/cattr/generics.py
new file mode 100644
index 00000000..8f638aff
--- /dev/null
+++ b/src/cattr/generics.py
@@ -0,0 +1,22 @@
+from typing import Any, Mapping
+
+from ._compat import copy_with, get_args, is_annotated, is_generic
+
+
+def deep_copy_with(t, mapping: Mapping[str, Any]):
+    args = get_args(t)
+    rest = ()
+    if is_annotated(t) and args:
+        # If we're dealing with `Annotated`, we only map the first type parameter
+        rest = tuple(args[1:])
+        args = (args[0],)
+    return copy_with(
+        t,
+        tuple(
+            mapping[a.__name__]
+            if hasattr(a, "__name__") and a.__name__ in mapping
+            else (deep_copy_with(a, mapping) if is_generic(a) else a)
+            for a in args
+        )
+        + rest,
+    )
diff --git a/tests/_compat.py b/tests/_compat.py
index 92a00fcd..5f163ceb 100644
--- a/tests/_compat.py
+++ b/tests/_compat.py
@@ -1,15 +1,22 @@
 from cattr._compat import is_bare, is_py37, is_py38
 
 if is_py37 or is_py38:
+    from typing import Dict, List
 
     def change_type_param(cl, new_params):
         if is_bare(cl):
             return cl[new_params]
         return cl.copy_with(new_params)
 
+    List_origin = List
+    Dict_origin = Dict
+
 
 else:
 
     def change_type_param(cl, new_params):
         cl.__args__ = (new_params,)
         return cl
+
+    List_origin = list
+    Dict_origin = dict
diff --git a/tests/test_generics.py b/tests/test_generics.py
index 421ac7b2..e0cb98d7 100644
--- a/tests/test_generics.py
+++ b/tests/test_generics.py
@@ -1,16 +1,39 @@
-from typing import Dict, Generic, List, TypeVar, Union
+from typing import Dict, Generic, List, Optional, TypeVar, Union
 
 import pytest
 from attr import asdict, attrs, define
 
 from cattr import Converter, GenConverter
-from cattr._compat import is_py39_plus
+from cattr._compat import Protocol, is_py39_plus
 from cattr.errors import StructureHandlerNotFoundError
+from cattr.generics import deep_copy_with
+
+from ._compat import Dict_origin, List_origin
+
+# if is_py37:
+#     from typing_extensions import Protocol
+# else:
+#     from typing import Protocol
 
 T = TypeVar("T")
 T2 = TypeVar("T2")
 
 
+def test_deep_copy():
+    """Test the deep copying of generic parameters."""
+    mapping = {T.__name__: int}
+    assert deep_copy_with(Optional[T], mapping) == Optional[int]
+    assert (
+        deep_copy_with(List_origin[Optional[T]], mapping)
+        == List_origin[Optional[int]]
+    )
+    mapping = {T.__name__: int, T2.__name__: str}
+    assert (
+        deep_copy_with(Dict_origin[T2, List_origin[Optional[T]]], mapping)
+        == Dict_origin[str, List_origin[Optional[int]]]
+    )
+
+
 @define
 class TClass(Generic[T, T2]):
     a: T
@@ -70,6 +93,22 @@ class GenericCols(Generic[T]):
     assert res == expected
 
 
+@pytest.mark.parametrize(
+    ("t", "result"), ((int, (1, [1, 2, 3])), (int, (1, None)))
+)
+def test_structure_nested_generics_with_cols(t, result):
+    @define
+    class GenericCols(Generic[T]):
+        a: T
+        b: Optional[List[T]]
+
+    expected = GenericCols(*result)
+
+    res = GenConverter().structure(asdict(expected), GenericCols[t])
+
+    assert res == expected
+
+
 @pytest.mark.parametrize(
     ("t", "t2", "result"),
     (
@@ -152,3 +191,63 @@ class OuterStr:
         inner: Inner[str]
 
     assert c.structure(raw, OuterStr) == OuterStr(Inner("1"))
+
+
+def test_unstructure_deeply_nested_generics():
+    c = GenConverter()
+
+    @define
+    class Inner:
+        a: int
+
+    @define
+    class Outer(Generic[T]):
+        inner: T
+
+    initial = Outer[Inner](Inner(1))
+    raw = c.unstructure(initial, Outer[Inner])
+    assert raw == {"inner": {"a": 1}}
+
+    raw = c.unstructure(initial)
+    assert raw == {"inner": {"a": 1}}
+
+
+def test_unstructure_deeply_nested_generics_list():
+    c = GenConverter()
+
+    @define
+    class Inner:
+        a: int
+
+    @define
+    class Outer(Generic[T]):
+        inner: List[T]
+
+    initial = Outer[Inner]([Inner(1)])
+    raw = c.unstructure(initial, Outer[Inner])
+    assert raw == {"inner": [{"a": 1}]}
+
+    raw = c.unstructure(initial)
+    assert raw == {"inner": [{"a": 1}]}
+
+
+def test_unstructure_protocol():
+    c = GenConverter()
+
+    class Proto(Protocol):
+        a: int
+
+    @define
+    class Inner:
+        a: int
+
+    @define
+    class Outer:
+        inner: Proto
+
+    initial = Outer(Inner(1))
+    raw = c.unstructure(initial, Outer)
+    assert raw == {"inner": {"a": 1}}
+
+    raw = c.unstructure(initial)
+    assert raw == {"inner": {"a": 1}}
diff --git a/tox.ini b/tox.ini
index 430e1160..0a67cfb0 100644
--- a/tox.ini
+++ b/tox.ini
@@ -10,6 +10,7 @@ python =
 [tox]
 envlist = pypy3, py37, py38, py39, py310, lint
 isolated_build = true
+skipsdist = true
 
 [testenv:lint]
 skip_install = true
@@ -30,7 +31,7 @@ setenv =
 extras = dev
 whitelist_externals = poetry
 commands =
-    poetry install -v --no-root
+    poetry install -v
     coverage run --source cattr -m pytest tests {posargs}
 passenv = CI