diff --git a/Lib/test/test_capi/test_mem.py b/Lib/test/test_capi/test_mem.py
index 6ab7b685c2e18b..0c2963cf6fa8c6 100644
--- a/Lib/test/test_capi/test_mem.py
+++ b/Lib/test/test_capi/test_mem.py
@@ -1,8 +1,8 @@
 import re
+import sys
 import textwrap
 import unittest
 
-
 from test import support
 from test.support import import_helper, requires_subprocess
 from test.support.script_helper import assert_python_failure, assert_python_ok
@@ -75,12 +75,20 @@ def check_malloc_without_gil(self, code):
     def test_pymem_malloc_without_gil(self):
         # Debug hooks must raise an error if PyMem_Malloc() is called
         # without holding the GIL
+        if support.check_sanitizer(thread=True) and sys.platform == 'darwin':
+            # See: gh-120696
+            raise unittest.SkipTest("this test will hang on macOS with TSAN")
+
         code = 'import _testcapi; _testcapi.pymem_malloc_without_gil()'
         self.check_malloc_without_gil(code)
 
     def test_pyobject_malloc_without_gil(self):
         # Debug hooks must raise an error if PyObject_Malloc() is called
         # without holding the GIL
+        if support.check_sanitizer(thread=True) and sys.platform == 'darwin':
+            # See: gh-120696
+            raise unittest.SkipTest("this test will hang on macOS with TSAN")
+
         code = 'import _testcapi; _testcapi.pyobject_malloc_without_gil()'
         self.check_malloc_without_gil(code)