diff --git a/example/grpc_client.js b/example/grpc_client.js
index 7cb230a..59b60b0 100644
--- a/example/grpc_client.js
+++ b/example/grpc_client.js
@@ -18,7 +18,10 @@ async function test() {
     serverHost: 'http://localhost:12200',
   });
   await consumer.ready();
-  const r = await consumer.invoke('SayHello', [{ name: 'peter' }]);
+  const r = await Promise.all([
+    consumer.invoke('SayHello', [{ name: 'peter' }]),
+    consumer.invoke('SayHi', [{ name: 'tony' }]),
+  ]);
   console.log(r);
 }
 
diff --git a/example/grpc_server.js b/example/grpc_server.js
index e360933..c62d8e0 100644
--- a/example/grpc_server.js
+++ b/example/grpc_server.js
@@ -22,6 +22,12 @@ server.addService({
       message: `hello ${req.name} from sofa-rpc-node`,
     };
   },
+  async SayHi(req) {
+    console.log(req);
+    return {
+      message: `hi ${req.name} from sofa-rpc-node`,
+    };
+  },
 });
 
 server.start();
diff --git a/example/proto/helloworld.proto b/example/proto/helloworld.proto
index be878ce..a413c9d 100644
--- a/example/proto/helloworld.proto
+++ b/example/proto/helloworld.proto
@@ -25,6 +25,7 @@ package helloworld;
 service Greeter {
   // Sends a greeting
   rpc SayHello (HelloRequest) returns (HelloReply) {}
+  rpc SayHi (HelloRequest) returns (HelloReply) {}
 }
 
 // The request message containing the user's name.
diff --git a/lib/client/connection/grpc/call_stream.js b/lib/client/connection/grpc/call_stream.js
index eed666d..3adbe44 100644
--- a/lib/client/connection/grpc/call_stream.js
+++ b/lib/client/connection/grpc/call_stream.js
@@ -206,6 +206,7 @@ class Http2CallStream extends Duplex {
     }
     this._endCall(err);
     this.destroy();
+    this.emit('close');
   }
 
   _attachHttp2Stream(stream) {
diff --git a/lib/server/grpc/response.js b/lib/server/grpc/response.js
index d579b01..947673b 100644
--- a/lib/server/grpc/response.js
+++ b/lib/server/grpc/response.js
@@ -29,11 +29,37 @@ class GRpcResponse {
 
   async send(res) {
     const methodInfo = this.methodInfo;
-    if (methodInfo.responseType) {
+    let http2Header = {
+      'content-type': 'application/grpc',
+      'grpc-accept-encoding': 'identity',
+      'accept-encoding': 'identity',
+    };
+    let grpcMeta = {
+      'grpc-status': 0,
+      'grpc-message': 'OK',
+    };
+    let data = '';
+    if (res.isError) {
+      this.meta.rt = Date.now() - this.meta.start;
+      this.meta.resultCode = '02';
+      http2Header = {
+        ...http2Header,
+        ':status': 500, // make a unknown http2 status
+      };
+      grpcMeta = {
+        ...grpcMeta,
+        'grpc-status': 2, // UNKNOWN
+        'grpc-message': res.errorMsg,
+      };
+      data = '';
+    } else if (methodInfo.responseType) {
       const responseEncodeStart = Date.now();
       const responseType = methodInfo.resolvedResponseType;
-      const buf = responseType.encode(responseType.fromObject(res.appResponse)).finish();
+      const buf = responseType
+        .encode(responseType.fromObject(res.appResponse))
+        .finish();
       const resSize = buf.length;
+      io.reset();
       io.put(0);
       io.putInt(resSize);
       io.put(buf);
@@ -42,21 +68,22 @@ class GRpcResponse {
       this.meta.data = buf;
       this.meta.rt = Date.now() - this.meta.start;
       this.meta.resSize = resSize + 5;
-
-      this.stream.respond({
-        ':status': 200,
-        'content-type': 'application/grpc',
-        'grpc-accept-encoding': 'identity',
-        'accept-encoding': 'identity',
-      }, { waitForTrailers: true });
-      this.stream.on('wantTrailers', () => {
-        this.stream.sendTrailers({
-          'grpc-status': 0,
-          'grpc-message': 'OK',
-        });
-      });
-      this.stream.end(io.array());
+      http2Header = { ...http2Header, ':status': 200 };
+      grpcMeta = {
+        ...grpcMeta,
+        'grpc-status': 0,
+        'grpc-message': 'OK',
+      };
+      data = io.array();
+    }
+    if (!this.stream || this.stream.destroyed) {
+      return;
     }
+    this.stream.respond(http2Header, { waitForTrailers: true });
+    this.stream.on('wantTrailers', () => {
+      this.stream.sendTrailers(grpcMeta);
+    });
+    this.stream.end(data);
   }
 }
 
diff --git a/lib/server/server.js b/lib/server/server.js
index 71018ed..fc85325 100644
--- a/lib/server/server.js
+++ b/lib/server/server.js
@@ -271,15 +271,17 @@ class RpcServer extends Base {
     this.emit('request', { req, ctx });
     try {
       if (!service) {
-        res.meta.resultCode = '02';
-        await res.send({
-          isError: true,
-          errorMsg: 'not found service: ' + id,
-          appResponse: null,
-        });
-      } else {
-        await service.invoke(ctx, req, res);
+        throw new Error('not found service: ' + id);
       }
+      await service.invoke(ctx, req, res);
+    } catch (e) {
+      this.emit('error', e);
+      res.meta.resultCode = '02';
+      await res.send({
+        isError: true,
+        errorMsg: e.message,
+        appResponse: e,
+      });
     } finally {
       this.emit('response', { ctx, req, res });
     }
diff --git a/lib/server/service.js b/lib/server/service.js
index 88e64c0..b30a53e 100644
--- a/lib/server/service.js
+++ b/lib/server/service.js
@@ -130,11 +130,12 @@ class RpcService extends Base {
       try {
         result = await method.apply(ctx, args);
       } catch (err) {
+        data.isError = true;
+        data.errorMsg = err.message;
         // 如果框架自身抛出的异常, error name 可以定义为 SystemError, 方便甄别
         // 这个异常直接放到协议头上
         if (err.name === 'SystemError') {
           res.meta.resultCode = err.resultCode || '02';
-          data.errorMsg = err.message;
         } else {
           // 业务异常
           res.meta.resultCode = err.resultCode || '01';
diff --git a/test/client/consumer.test.js b/test/client/consumer.test.js
index 64ad8d1..cc8ff1b 100644
--- a/test/client/consumer.test.js
+++ b/test/client/consumer.test.js
@@ -389,7 +389,7 @@ describe('test/client/consumer.test.js', () => {
     assert(!req.meta.crcEnable);
     assert(req.meta.timeout === 3000);
     assert(req.meta.reqSize === 271);
-    assert(req.meta.resSize === 113);
+    assert(req.meta.resSize === 112);
     assert(req.meta.rt >= 0);
 
     assert(res && res.error && res.error.message.includes('mock error'));
diff --git a/test/fixtures/proto/helloworld.proto b/test/fixtures/proto/helloworld.proto
index be878ce..795ae2c 100644
--- a/test/fixtures/proto/helloworld.proto
+++ b/test/fixtures/proto/helloworld.proto
@@ -25,6 +25,7 @@ package helloworld;
 service Greeter {
   // Sends a greeting
   rpc SayHello (HelloRequest) returns (HelloReply) {}
+  rpc SayHi (HiRequest) returns (HiReply) {}
 }
 
 // The request message containing the user's name.
@@ -36,3 +37,11 @@ message HelloRequest {
 message HelloReply {
   string message = 1;
 }
+
+message HiRequest {
+  string name = 1;
+}
+
+message HiReply {
+  string message = 1;
+}
diff --git a/test/grpc/index.test.js b/test/grpc/index.test.js
index 656a0c5..f64347a 100644
--- a/test/grpc/index.test.js
+++ b/test/grpc/index.test.js
@@ -21,16 +21,28 @@ describe('test/grpc/index.test.js', () => {
       logger,
       port,
     });
-    server.addService({
-      interfaceName: 'helloworld.Greeter',
-    }, {
-      async SayHello(req) {
-        await sleep(200);
-        return {
-          message: `hello ${req.name}`,
-        };
+    server.addService(
+      {
+        interfaceName: 'helloworld.Greeter',
       },
-    });
+      {
+        async SayHello(req) {
+          await sleep(200);
+          return {
+            message: `hello ${req.name}`,
+          };
+        },
+        async SayHi(req) {
+          await sleep(100);
+          if (req.name === 'throw') {
+            throw new Error('test error message');
+          }
+          return {
+            message: `hi ${req.name}`,
+          };
+        },
+      }
+    );
     await server.start();
     client = new GRpcClient({
       proto,
@@ -85,4 +97,34 @@ describe('test/grpc/index.test.js', () => {
       .invoke('SayHello', { name: 'world' })
       .expect({ message: 'hello world' });
   });
+
+  it('should invoke gRPC multi times works fine', async function() {
+    const helloResult = await request(server)
+      .service('helloworld.Greeter')
+      .invoke('SayHello', { name: 'world' });
+    helloResult.consumer.close();
+    assert.deepEqual(helloResult.data, { message: 'hello world' });
+    const hiResult = await request(server)
+      .service('helloworld.Greeter')
+      .invoke('SayHi', { name: 'world' });
+    hiResult.consumer.close();
+    assert.deepEqual(hiResult.data, { message: 'hi world' });
+  });
+
+  it('should get error response when service throw exception', async function() {
+    const consumer = client.createConsumer({
+      interfaceName: 'helloworld.Greeter',
+      serverHost: 'http://localhost:' + port,
+    });
+    await consumer.ready();
+    try {
+      await consumer.invoke('SayHi', [{ name: 'throw' }], {});
+      assert(false);
+    } catch (e) {
+      assert(e.code === 2);
+      assert(e.message === 'test error message');
+    } finally {
+      consumer.close();
+    }
+  });
 });
diff --git a/test/test/index.test.js b/test/test/index.test.js
index 53f3c2a..0a42629 100644
--- a/test/test/index.test.js
+++ b/test/test/index.test.js
@@ -413,7 +413,7 @@ describe('test/test/index.test.js', () => {
             assert(false, 'should no run here');
           })
           .catch(err => {
-            assert(err.message === 'Error: mock error');
+            assert(err.message.includes('Error: mock error'));
           });
       });
     });