diff --git a/src/main/java/org/tikv/common/operation/RegionErrorHandler.java b/src/main/java/org/tikv/common/operation/RegionErrorHandler.java
index 9aa678b41e7..68237df3ba2 100644
--- a/src/main/java/org/tikv/common/operation/RegionErrorHandler.java
+++ b/src/main/java/org/tikv/common/operation/RegionErrorHandler.java
@@ -130,9 +130,12 @@ public boolean handleRegionError(BackOffer backOffer, Errorpb.Error error) {
           BackOffFunction.BackOffFuncType.BoServerBusy,
           new StatusRuntimeException(
               Status.fromCode(Status.Code.UNAVAILABLE).withDescription(error.toString())));
+      return true;
+    } else if (error.hasRegionNotFound()) {
       backOffer.doBackOff(
           BackOffFunction.BackOffFuncType.BoRegionMiss, new GrpcException(error.getMessage()));
-      return true;
+      this.regionManager.onRegionStale(recv.getRegion());
+      return false;
     } else if (error.hasStaleCommand()) {
       // this error is reported from raftstore:
       // command outdated, please try later
diff --git a/src/main/java/org/tikv/common/region/AbstractRegionStoreClient.java b/src/main/java/org/tikv/common/region/AbstractRegionStoreClient.java
index c47bb854746..ba6422a8eca 100644
--- a/src/main/java/org/tikv/common/region/AbstractRegionStoreClient.java
+++ b/src/main/java/org/tikv/common/region/AbstractRegionStoreClient.java
@@ -272,7 +272,7 @@ private boolean retryOtherStoreByProxyForward() {
     }
     if (originStore == null) {
       originStore = targetStore;
-      if (this.targetStore.getProxyStore() != null) {
+      if (this.targetStore.getProxyStore() != null && this.timeout < conf.getForwardTimeout()) {
         this.timeout = conf.getForwardTimeout();
       }
     }
diff --git a/src/main/java/org/tikv/common/util/ConcreteBackOffer.java b/src/main/java/org/tikv/common/util/ConcreteBackOffer.java
index a7af12b85c1..1148f64ea50 100644
--- a/src/main/java/org/tikv/common/util/ConcreteBackOffer.java
+++ b/src/main/java/org/tikv/common/util/ConcreteBackOffer.java
@@ -86,29 +86,29 @@ public static ConcreteBackOffer create(BackOffer source) {
   private BackOffFunction createBackOffFunc(BackOffFunction.BackOffFuncType funcType) {
     BackOffFunction backOffFunction = null;
     switch (funcType) {
-      case BoUpdateLeader:
-        backOffFunction = BackOffFunction.create(1, 10, BackOffStrategy.NoJitter);
-        break;
       case BoTxnLockFast:
         backOffFunction = BackOffFunction.create(100, 3000, BackOffStrategy.EqualJitter);
         break;
+      case BoTxnLock:
+        backOffFunction = BackOffFunction.create(200, 3000, BackOffStrategy.EqualJitter);
+        break;
+      case BoTxnNotFound:
+        backOffFunction = BackOffFunction.create(2, 500, BackOffStrategy.NoJitter);
+        break;
       case BoServerBusy:
-        backOffFunction = BackOffFunction.create(2000, 10000, BackOffStrategy.EqualJitter);
+        backOffFunction = BackOffFunction.create(40, 5120, BackOffStrategy.EqualJitter);
         break;
-      case BoRegionMiss:
-        backOffFunction = BackOffFunction.create(100, 500, BackOffStrategy.NoJitter);
+      case BoUpdateLeader:
+        backOffFunction = BackOffFunction.create(1, 10, BackOffStrategy.NoJitter);
         break;
-      case BoTxnLock:
-        backOffFunction = BackOffFunction.create(200, 3000, BackOffStrategy.EqualJitter);
+      case BoRegionMiss:
+        backOffFunction = BackOffFunction.create(10, 640, BackOffStrategy.NoJitter);
         break;
       case BoPDRPC:
-        backOffFunction = BackOffFunction.create(100, 600, BackOffStrategy.EqualJitter);
+        backOffFunction = BackOffFunction.create(10, 640, BackOffStrategy.EqualJitter);
         break;
       case BoTiKVRPC:
-        backOffFunction = BackOffFunction.create(100, 400, BackOffStrategy.EqualJitter);
-        break;
-      case BoTxnNotFound:
-        backOffFunction = BackOffFunction.create(2, 500, BackOffStrategy.NoJitter);
+        backOffFunction = BackOffFunction.create(10, 640, BackOffStrategy.EqualJitter);
         break;
     }
     return backOffFunction;