diff --git a/src/main/java/org/tikv/common/operation/RegionErrorHandler.java b/src/main/java/org/tikv/common/operation/RegionErrorHandler.java
index 2e4ab56b041..d6b5bb06029 100644
--- a/src/main/java/org/tikv/common/operation/RegionErrorHandler.java
+++ b/src/main/java/org/tikv/common/operation/RegionErrorHandler.java
@@ -224,7 +224,14 @@ private boolean onRegionEpochNotMatch(BackOffer backOffer, List<Metapb.Region> c
   @Override
   public boolean handleRequestError(BackOffer backOffer, Exception e) {
     if (recv.onStoreUnreachable()) {
-      backOffer.doBackOff(BackOffFunction.BackOffFuncType.BoTiKVRPC, e);
+      try {
+        backOffer.doBackOff(BackOffFunction.BackOffFuncType.BoTiKVRPC, e);
+      } catch (Exception boErr) {
+        logger.warn(
+            String.format("backoff time exceed, invalidate region[%d]", recv.getRegion().getId()));
+        regionManager.onRequestFail(recv.getRegion());
+        throw boErr;
+      }
       return true;
     }
 
diff --git a/src/main/java/org/tikv/common/region/AbstractRegionStoreClient.java b/src/main/java/org/tikv/common/region/AbstractRegionStoreClient.java
index c47bb854746..bb8998ba44f 100644
--- a/src/main/java/org/tikv/common/region/AbstractRegionStoreClient.java
+++ b/src/main/java/org/tikv/common/region/AbstractRegionStoreClient.java
@@ -144,7 +144,9 @@ public boolean onStoreUnreachable() {
     // reduce the latency cost by fail requests.
     if (targetStore.canForwardFirst()) {
       if (conf.getEnableGrpcForward() && retryForwardTimes <= region.getFollowerList().size()) {
-        return retryOtherStoreByProxyForward();
+        if (retryOtherStoreByProxyForward()) {
+          return true;
+        }
       }
       if (retryOtherStoreLeader()) {
         return true;
@@ -154,7 +156,9 @@ public boolean onStoreUnreachable() {
         return true;
       }
       if (conf.getEnableGrpcForward() && retryForwardTimes <= region.getFollowerList().size()) {
-        return retryOtherStoreByProxyForward();
+        if (retryOtherStoreByProxyForward()) {
+          return true;
+        }
       }
       return true;
     }