diff --git a/src/main/java/org/tikv/common/operation/RegionErrorHandler.java b/src/main/java/org/tikv/common/operation/RegionErrorHandler.java
index 2e4ab56b041..cec220440c3 100644
--- a/src/main/java/org/tikv/common/operation/RegionErrorHandler.java
+++ b/src/main/java/org/tikv/common/operation/RegionErrorHandler.java
@@ -224,15 +224,19 @@ private boolean onRegionEpochNotMatch(BackOffer backOffer, List<Metapb.Region> c
   @Override
   public boolean handleRequestError(BackOffer backOffer, Exception e) {
     if (recv.onStoreUnreachable()) {
-      backOffer.doBackOff(BackOffFunction.BackOffFuncType.BoTiKVRPC, e);
+      if (!backOffer.canRetryAfterSleep(BackOffFunction.BackOffFuncType.BoTiKVRPC)) {
+        regionManager.onRequestFail(recv.getRegion());
+        throw new GrpcException("retry is exhausted.", e);
+      }
       return true;
     }
 
     logger.warn("request failed because of: " + e.getMessage());
-    backOffer.doBackOff(
-        BackOffFunction.BackOffFuncType.BoTiKVRPC,
-        new GrpcException(
-            "send tikv request error: " + e.getMessage() + ", try next peer later", e));
+    if (!backOffer.canRetryAfterSleep(BackOffFunction.BackOffFuncType.BoTiKVRPC)) {
+      regionManager.onRequestFail(recv.getRegion());
+      throw new GrpcException(
+          "send tikv request error: " + e.getMessage() + ", try next peer later", e);
+    }
     // TiKV maybe down, so do not retry in `callWithRetry`
     // should re-fetch the new leader from PD and send request to it
     return false;
diff --git a/src/main/java/org/tikv/common/region/AbstractRegionStoreClient.java b/src/main/java/org/tikv/common/region/AbstractRegionStoreClient.java
index c47bb854746..fcfd88cc50c 100644
--- a/src/main/java/org/tikv/common/region/AbstractRegionStoreClient.java
+++ b/src/main/java/org/tikv/common/region/AbstractRegionStoreClient.java
@@ -143,8 +143,8 @@ public boolean onStoreUnreachable() {
     // so that we can
     // reduce the latency cost by fail requests.
     if (targetStore.canForwardFirst()) {
-      if (conf.getEnableGrpcForward() && retryForwardTimes <= region.getFollowerList().size()) {
-        return retryOtherStoreByProxyForward();
+      if (retryOtherStoreByProxyForward()) {
+        return true;
       }
       if (retryOtherStoreLeader()) {
         return true;
@@ -153,12 +153,10 @@ public boolean onStoreUnreachable() {
       if (retryOtherStoreLeader()) {
         return true;
       }
-      if (conf.getEnableGrpcForward() && retryForwardTimes <= region.getFollowerList().size()) {
-        return retryOtherStoreByProxyForward();
+      if (retryOtherStoreByProxyForward()) {
+        return true;
       }
-      return true;
     }
-
     logger.warn(
         String.format(
             "retry time exceed for region[%d], invalid this region[%d]",
@@ -262,6 +260,9 @@ private void updateClientStub() {
   }
 
   private boolean retryOtherStoreByProxyForward() {
+    if (!conf.getEnableGrpcForward() || retryForwardTimes > region.getFollowerList().size()) {
+      return false;
+    }
     TiStore proxyStore = switchProxyStore();
     if (proxyStore == null) {
       logger.warn(
diff --git a/src/main/java/org/tikv/common/util/BackOffer.java b/src/main/java/org/tikv/common/util/BackOffer.java
index 951700008f2..b5081a39b5c 100644
--- a/src/main/java/org/tikv/common/util/BackOffer.java
+++ b/src/main/java/org/tikv/common/util/BackOffer.java
@@ -33,6 +33,12 @@ public interface BackOffer {
    * max back off time exceeded and throw an exception to the caller.
    */
   void doBackOff(BackOffFunction.BackOffFuncType funcType, Exception err);
+  /**
+   * canRetryAfterSleep sleeps a while base on the BackOffType and records the error message. Will
+   * stop until max back off time exceeded and throw an exception to the caller. It will return
+   * false if the total sleep time has exceed some limit condition.
+   */
+  boolean canRetryAfterSleep(BackOffFunction.BackOffFuncType funcType);
 
   /**
    * BackoffWithMaxSleep sleeps a while base on the backoffType and records the error message and
diff --git a/src/main/java/org/tikv/common/util/ConcreteBackOffer.java b/src/main/java/org/tikv/common/util/ConcreteBackOffer.java
index 1b082319f7a..173109a1cbc 100644
--- a/src/main/java/org/tikv/common/util/ConcreteBackOffer.java
+++ b/src/main/java/org/tikv/common/util/ConcreteBackOffer.java
@@ -146,47 +146,55 @@ public void doBackOff(BackOffFunction.BackOffFuncType funcType, Exception err) {
   }
 
   @Override
-  public void doBackOffWithMaxSleep(
-      BackOffFunction.BackOffFuncType funcType, long maxSleepMs, Exception err) {
+  public boolean canRetryAfterSleep(BackOffFunction.BackOffFuncType funcType) {
+    return canRetryAfterSleep(funcType, -1);
+  }
+
+  public boolean canRetryAfterSleep(BackOffFunction.BackOffFuncType funcType, long maxSleepMs) {
     Histogram.Timer backOffTimer = BACKOFF_DURATION.labels(funcType.name()).startTimer();
-    try {
-      BackOffFunction backOffFunction =
-          backOffFunctionMap.computeIfAbsent(funcType, this::createBackOffFunc);
-
-      // Back off will not be done here
-      long sleep = backOffFunction.getSleepMs(maxSleepMs);
-      totalSleep += sleep;
-
-      logger.debug(
-          String.format(
-              "%s, retry later(totalSleep %dms, maxSleep %dms)",
-              err.getMessage(), totalSleep, maxSleep));
-      errors.add(err);
-
-      // Check deadline
-      if (deadline > 0) {
-        long currentMs = System.currentTimeMillis();
-        if (currentMs + sleep >= deadline) {
-          logThrowError(String.format("Deadline %d is exceeded, errors:", deadline), err);
-        }
+    BackOffFunction backOffFunction =
+        backOffFunctionMap.computeIfAbsent(funcType, this::createBackOffFunc);
+
+    // Back off will not be done here
+    long sleep = backOffFunction.getSleepMs(maxSleepMs);
+    totalSleep += sleep;
+    // Check deadline
+    if (deadline > 0) {
+      long currentMs = System.currentTimeMillis();
+      if (currentMs + sleep >= deadline) {
+        logger.warn(String.format("Deadline %d is exceeded, errors:", deadline));
+        return false;
       }
+    }
 
-      try {
-        Thread.sleep(sleep);
-      } catch (InterruptedException e) {
-        throw new GrpcException(e);
-      }
+    try {
+      Thread.sleep(sleep);
+    } catch (InterruptedException e) {
+      throw new GrpcException(e);
+    }
+    backOffTimer.observeDuration();
+    if (maxSleep > 0 && totalSleep >= maxSleep) {
+      logger.warn(String.format("BackOffer.maxSleep %dms is exceeded, errors:", maxSleep));
+      return false;
+    }
+    return true;
+  }
 
-      if (maxSleep > 0 && totalSleep >= maxSleep) {
-        logThrowError(String.format("BackOffer.maxSleep %dms is exceeded, errors:", maxSleep), err);
-      }
-    } finally {
-      backOffTimer.observeDuration();
+  @Override
+  public void doBackOffWithMaxSleep(
+      BackOffFunction.BackOffFuncType funcType, long maxSleepMs, Exception err) {
+    logger.debug(
+        String.format(
+            "%s, retry later(totalSleep %dms, maxSleep %dms)",
+            err.getMessage(), totalSleep, maxSleep));
+    errors.add(err);
+    if (!canRetryAfterSleep(funcType, maxSleepMs)) {
+      logThrowError(err);
     }
   }
 
-  private void logThrowError(String msg, Exception err) {
-    StringBuilder errMsg = new StringBuilder(msg);
+  private void logThrowError(Exception err) {
+    StringBuilder errMsg = new StringBuilder();
     for (int i = 0; i < errors.size(); i++) {
       Exception curErr = errors.get(i);
       // Print only last 3 errors for non-DEBUG log levels.