Tox 4.0 is a fairly massive shift in internals even if the migration guide doesn't seem too bad.
We shipped tox-monorepo for tox<4. This enables us to re-use the same tox.ini file regardless of where we're starting from. You just need to provide the relative path to the tox.ini we use.
This issue covers support for tox>=4, and all the changes that are necessary to enable that.