The `BLOSC_DIR` build environment variable does not seem to be used anywhere. A search on the repository only shows https://github.com/Blosc/python-blosc/search?q=BLOSC_DIR&unscoped_q=BLOSC_DIR : - https://github.com/Blosc/python-blosc/blob/v1.8.3/doc/install.rst#compiling-with-an-installed-blosc-library - https://github.com/Blosc/python-blosc/blob/v1.8.3/README.rst#compiling-with-an-installed-blosc-library - https://github.com/Blosc/python-blosc/blob/v1.8.3/setup.py#L97 The `install.rst` and `README.rst` also have to be amended to remove the `--blosc=/usr/local` option.