This exception is currently being thrown on master branch (commit 3a59bc1ae09c7fed4af4dd077c02d5abe9e097ad):
art@Wernstrom OpenRDP % python3 -i -m openrdp tests/test_neisseria.fasta test.csv -cfg tests/test_cfg.ini -all
Starting 3Seq Analysis
[Errno 2] No such file or directory: '/Users/art/git/OpenRDP/test_neisseria.fasta.3s.rec'
Finished 3Seq Analysis