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To run the program

  1. fill-up parameter values in the file "parameters" as follows

    ** b1: ceRNA_1 synthesis rate ** b2: ceRNA_2 synthesis rate ** beta: miRNA synthesis rate ** d1: ceRNA_1 degradation rate ** d2: ceRNA_2 degradation rate ** delta: miRNA degradation rate ** sigma1: complex_1 stoichiometric decay rate ** sigma2: complex_2 stoichiometric decay rate ** k1pl: complex_1 association rate ** k2pl: complex_2 association rate ** k1min: complex_1 dissociation rate ** k2min: complex_2 dissociation rate ** kappa1: complex_1 catalytic decay rate ** kappa2: complex_2 catalytic decay rate ** n1: TF_1 occupancy ** n2: TF_2 occupancy ** nmu: TF_mu occupancy ** h: number of cooperatively binding TF molecules ** kin: TF binding rate ** kout: TF unbinding rate ** fmax: maximum number of input TF molecules ** fmin: minimum number of input TF molecules ** m2min: minimum size of the target population ** m2max: maximum size of the target population ** channel: assign 1 for the miRNA-channel and 2 for the TF-channel ** step: advancement of input TF ** MC_steps: number of Monte-Carlo steps ** MC_eq: number of Monte-Carlo steps to equilibrate the system

  2. make sure that you have g++ compiler

  3. run the bash script "bash.sh"

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estimating the effectiveness of ceRNA effect

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