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Major update deepCSA#26

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FerriolCalvet merged 12 commits intomainfrom
4-subworkflow-mutational-profile
Jan 9, 2024
Merged

Major update deepCSA#26
FerriolCalvet merged 12 commits intomainfrom
4-subworkflow-mutational-profile

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@FerriolCalvet
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I connected the following subworkflows:

  • Mutation preprocessing
  • Mutation profile & mutabilities
  • Oncodrive3D
  • OncodriveFML

and started preparing omega.

Features:
- Filter mutations with JSON file.
- Single sample or multiple samples.
- Introduction of possible BED files tunning per sample.
- New inputsingle.csv file
Pending:
-  See if write maf can be implemented in filterbatch
Features:
- Add mut. profile plotting capabilities.
- To do: revise if JSON or TSV output
Features:
- Compute trinucleotides from annotated depths matrix
- Compute mut. profile using the sample specific trinuc.
- Add some specific command line options through modules.config
Missing:
- Option within matrix computation to adjust to genomic trinuc. counts.
- Repeat test with proper depths file.
Features:
- Compute mutability for all positions using profile and depths.
- Compress and index mutabilities with tabix.
Missing:
- *Handling of all samples together.*
- *Depth files for individual samples and for joined batches.*
Features:
- Subsetting MAF module and script.
- Oncodrive3D/FML modules updated with meta
- Updated mutation matrix creation filter to use subset MAF module.
- Added germline and depth thresholds.
Features:
- Handle Ns in CONTEXT.
- Duplicated positions when expanding the panel.
- Define basic test and duplexome test.
- Remove unnecessary input.
Features:
- Update Oncodrive3d container.
- Add error strategy ignore since oncodrive3d failed in the duplexome.
This was linked to issues Jan 9, 2024
@FerriolCalvet FerriolCalvet self-assigned this Jan 9, 2024
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all good!

@FerriolCalvet FerriolCalvet merged commit f779bc4 into main Jan 9, 2024
@FerriolCalvet FerriolCalvet linked an issue Jan 9, 2024 that may be closed by this pull request
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@FerriolCalvet FerriolCalvet deleted the 4-subworkflow-mutational-profile branch February 19, 2024 15:26
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Mutation preparation module Add oncodrive3d SUBWORKFLOW: mutational profile

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