Using the Canary version of Spin, a guest (Spin component), is no longer able to set the host header on outbound http requests.
This change in Wasmtime is what impacts this: bytecodealliance/wasmtime#7905. It was incorporated in Spin with Wasmtime 21.0.1 #2538.
Currently looking in to a potential update to Wasmtime to relax and still allow host headers to be set from the guest.