If something within a web app increases the line size above 1MB, then Apache's mod_substitue can cause issues. An easy fix is to increase "SubstituteMaxLineLength". From my brief reading, it seems that a larger "SubstituteMaxLineLength" can make DoS attacks easier. However, we have mod_evasive pre-installed and enabled, so that should not pose an issue. 10M seems a common size to bump it to.
So add this line here:
SubstituteMaxLineLength 10M