A web application for testing gene overlap between user-defined modules and reference modules across datasets. It helps researchers identify statistically significant overlaps and explore shared genes.
Live app: https://overlapmodule.onrender.com
This tool was developed as part of:
Li H, Xie Z, Tian Y, et al.
Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer’s disease and epilepsy.
Molecular Psychiatry (2026) 31:1774–1784
DOI: 10.1038/s41380-025-03318-0
It enables researchers to validate and compare gene modules against the consensus modules described in the study.
- Upload gene-module data (CSV or Excel)
- Compare with built-in or custom reference datasets
- Statistical testing:
- Fisher’s Exact Test
- Hypergeometric Test
- Multiple testing correction (Benjamini–Hochberg)
- Interactive heatmap visualization
- Adjustable thresholds and filters
- Download overlapping gene lists