Skip to content

SUBWORKFLOW: omega #14

@FerriolCalvet

Description

@FerriolCalvet
  • Container for omega
  • Omega preprocessing module
  • Omega running module
  • Create sample/gene/consequence grouping JSON.
  • OmegaGlobalLoc #87
// SUBWORKFLOW: omega
// Description:
//     - Compute positive selection based on mutation recurrence.
// Input:
//     - Depths
//     - Mutations
//     - Mutation profile
//     - Regions to focus the analysis annotated (pending to update omega version with this working)
//     - Sample gene and consequence groups. (set defaults: all samples independent, all samples together
//                                                             all genes independent, all genes together,
//                                                                         all genes in the analysis that are known cancer genes,
//                                                             set default consequence types
//                                                             )
// Output:
//     - omega results
//     - Plots ?

// Modules:
//     - Intersect regions bedfile with depths
//     - Intersect the intersection of the previous two files with the mutations
//     - Omega preprocessing module
//     - Omega estimator module
//     - Plot results:
//             Ideas:
//                 Clustermap of all individual samples
//                 Sanger-like, with number of mutations per type with all samples, and then positive selection for each of the impacts
//                 Positive selection per each of the genes.

Metadata

Metadata

Assignees

Labels

new-featureNew functionality being added.

Type

No type

Projects

No projects

Milestone

No milestone

Relationships

None yet

Development

No branches or pull requests

Issue actions